Dual-functional guanosine-based hydrogel integrating localized delivery and anticancer activities for cancer therapy

Zhao, Hang; Feng, Hui; Liu, Jiang; Tang, Fan; Du, Yu; Ji, Ning; Xie, Liang; Zhao, Xuefeng; Zhi-yong, Wang; Chen, Qianming

doi:10.1016/j.biomaterials.2019.119598

Cited by 66 publications

(59 citation statements)

References 51 publications

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“…[122][123][124][125] Some hydrogels integrate interior antitumor activity with localized delivery in one system. 126 Localized cancer treatment by hydrogels can replace the need for systemic chemotherapy administered intravenously or orally. [127][128][129][130] With the development of multifunctional hydrogels, their applications are not limited to tissue repair but also extend to tumor cure and bone repair.…”

Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

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Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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“…The reported isoguanosine-borate-guanosine based hydrogel exhibited highly anti-tumor activities and show excellent inhibition effect of tumor recurrence. [68] Fmoc-L-phenylalanine (Fmoc-F) based supramolecular hybrid gel was formed through interacting with halloysite nanotubes (f-HNT). This hybrid gel was used as the carrier for the anticancer drug camptothecin (CPT).…”

Section: Fabrication and Release Mechanism Of Anticancer Drug Loaded mentioning

confidence: 99%

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

et al. 2020

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Conceptualising gelators with stimuli responsiveness is advantageous to design smart materials for emerging technologies. These gelators, if are surface active and made up of active pharmaceutical ingredients, can (i) exhibit an interesting pharmaceutical profile, (ii) be useful in drug formulations and (iii) exert direct effects on cell membranes. Herein, cetylpyridinium salicylate (CetPySal) that offers higher surface activity than its precursor surfactant, cetpylpyridinium chloride (CPCl), was synthesised. CetPySal forms a temperature‐responsive ionogel at a critical gelation concentration that changes its physical appearance with temperature, i. e. opaque to transparent, owing to its structural arrangement within its supramolecular framework, that are characterized through spectrometric, calorimetric, scattering and microscopic techniques. The viscoelastic nature of the ionogels was studied through dynamic rheological measurements and the interactions that governs the phase transition were studied through FTIR spectroscopy. The hybrid pharmaceutical ionogels was successfully constructed through encapsulation of the chemotherapeutic drug imatinib mesylate within the ionogel matrix. The sustained release of the drug was investigated from this hybrid ionogel matrix. These results suggest that this new thermo‐responsive ionogel may be used to improve sustained release of drugs and open up new avenues as low‐cost gelators for biomedical applications.

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“…[17][18][19] However, poor lifetime stability of guanosine hydrogels restricts them to use for various applications. In this regard, more stable guanosine-borate based multicomponent self-assembled hydrogels [20] have been recognized in potential biological applications such as antibacterial activity, [21] antitumor activity, [22] drug delivery, [23,24] 3D bioprinting [25] and other areas such as sensor, electronic device. [26][27][28] However, to the best of our knowledge, boronate ester directed G-quadruplex hydrogels have not been explored as a template for in situ synthesis of metal NPs.…”

Section: Introductionmentioning

confidence: 99%

Pt Nanoparticles Supported on a Dynamic Boronate Ester‐Based G‐quadruplex Hydrogel as a Nanoreactor

Ghosh

Biswas

Bhowmik

et al. 2020

Chemistry An Asian Journal

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Herein, we have reported a dynamic boronic ester mediated guanosine (G) based G-quadruplex hydrogel as an ideal template for in situ and 'green chemical' approach for the synthesis and stabilization of Pt NPs. 11 B NMR and FT-IR spectra reveal the formation of dynamic boronate ester bonds. The TEM images of the G-quadruplex hydrogel reveal entangled three-dimensional (3D) crosslink nanofibrillar networks with average diameter of 20 nm. Similarly, AFM images of the hydrogel show dense nanofibrillar assembly with an average height of 6 nm. The in situ generated Pt NPs have been characterized using TEM and XPS techniques. The average size of the nanofiber supported Pt NPs is 1.5 nm. The Pt NPs embedded G-quadruplex hydrogel shows better mechanical stiffness than the native hydrogel as the storage modulus (G') increases to 2250 Pa from 317.08 Pa after the in situ generation of Pt NPs. Furthermore, G-quadruplex hydrogel supported Pt NPs have been used as a catalytic system for hydrogenation reaction of different aromatic nitro compounds in aqueous medium. The use of G-quadruplex molecular system as a template for the synthesis and stabilization of metal NPs would be an interesting area of research.

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Dual-functional guanosine-based hydrogel integrating localized delivery and anticancer activities for cancer therapy

Cited by 66 publications

References 51 publications

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

Pt Nanoparticles Supported on a Dynamic Boronate Ester‐Based G‐quadruplex Hydrogel as a Nanoreactor

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