Pt Nanoparticles Supported on a Dynamic Boronate Ester‐Based G‐quadruplex Hydrogel as a Nanoreactor

Abstract

Herein, we have reported a dynamic boronic ester mediated guanosine (G) based G-quadruplex hydrogel as an ideal template for in situ and 'green chemical' approach for the synthesis and stabilization of Pt NPs. 11 B NMR and FT-IR spectra reveal the formation of dynamic boronate ester bonds. The TEM images of the G-quadruplex hydrogel reveal entangled three-dimensional (3D) crosslink nanofibrillar networks with average diameter of 20 nm. Similarly, AFM images of the hydrogel show dense nanofibrillar assembly with an average height of 6 nm. The in situ generated Pt NPs have been characterized using TEM and XPS techniques. The average size of the nanofiber supported Pt NPs is 1.5 nm. The Pt NPs embedded G-quadruplex hydrogel shows better mechanical stiffness than the native hydrogel as the storage modulus (G') increases to 2250 Pa from 317.08 Pa after the in situ generation of Pt NPs. Furthermore, G-quadruplex hydrogel supported Pt NPs have been used as a catalytic system for hydrogenation reaction of different aromatic nitro compounds in aqueous medium. The use of G-quadruplex molecular system as a template for the synthesis and stabilization of metal NPs would be an interesting area of research.

Nucleopeptide-Coupled Injectable Bioconjugated Guanosine-Quadruplex Hydrogel with Inherent Antibacterial Activity

“…Therefore, the formation of imino-boronate ester bonds was characterized by FT-IR (Figure 2a) and 11 of G from 1729 to 1684 cm −1 in the G4NP hydrogel indicates the formation of the H-bonded G-quartet structure. 52,53 Again, the intensity of the free −NH 2 stretching frequency at 3205 cm −1 decreases after the formation of the G4NP hydrogel, suggesting the formation of an imine bond between the free amine of the NP and the aldehyde group of 4-FPBA. Furthermore, we have analyzed the 1 H NMR spectroscopy of the G4NP hydrogel to confirm the formation of imine bonds due to the reaction between the NP and 4-FPBA.…”

A platinum nanoparticle doped self-assembled peptide bolaamphiphile hydrogel as an efficient electrocatalyst for the hydrogen evolution reaction

“…Recent studies have shown that the mechanical stability of hydrogels could be largely affected by the presence of NPs. 59,60 To investigate whether the rheological performance of hybrid Pt@hydrogel was influenced by inclusion Pt nanoparticles, we carried out rheological studies at a given concentration of 20 mM. The oscillatory frequency sweep analysis of Pt@hydrogel (Figure 2a) reveals that the storage modulus (G') and loss modulus The formation of Pt NPs over peptide bolaamphiphile nanofiber was further confirmed by Xray photoelectron spectroscopy (XPS).…”

Dynamic Multicomponent Reactions Directed Self-assembled G-quadruplex Inherent Antibacterial Hydrogel

“…This dynamic boronate ester bond is the key component of this dynamic G-quadruplex hydrogels. 48,49 The FT-IR spectra of 2-FPBA shows a stretching frequency peak at 1355 cm -1 corresponding to the B-O-H bond. The appearance of a peak at 1108 cm -1 for all the dried hydrogels dictates the formation of B-O-C bond.…”