Dual-frequency electrical impedance mammography for the diagnosis of non-malignant breast disease

Trokhanova, O V; Okhapkin, M B; Korjenevsky, A V

doi:10.1088/0967-3334/29/6/s28

Cited by 28 publications

(14 citation statements)

References 5 publications

(9 reference statements)

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“…The reversible electroporation threshold and the irreversible one are fixed at 400 and 800 V/cm respectively [ 32 ]. The initial values were set: for the tumor σ = 0.55 S/m, as suggested in [ 33 - 35 ] for the breast cancer, and for the surrounding box σ = 0.04 S/m as in [ 33 , 36 , 37 ] for mammalian tissue with high percentage of fat.…”

Section: Methodsmentioning

confidence: 99%

Modeling the positioning of single needle electrodes for the treatment of breast cancer in a clinical case

Denzi¹,

Strigari

Filippo³

et al. 2015

BioMed Eng OnLine

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BackgroundBreast cancer is the most common cancer in women worldwide and is the second most common cause of cancer death in women. Electrochemotherapy (ECT) used in early-phase clinical trials for the treatment of primary breast cancer resulted in a not complete tumor necrosis in most cases. The present study was undertaken to analyze the feasibility to use ECT to treat patients with histologically proven unifocal ductal breast cancer. In particular, results of ECT treatment in a clinical case are compared with the ones of a simplified 3D dosimetric model.MethodsThis clinical study was conducted with the pulse generator Cliniporator Vitae (IGEA, Carpi, Italy). ECT procedures were performed according to ESOPE standard operating procedures. Five single needle electrodes were used with one positioned in the center of the tumor, and the other four distributed around the nodule. Histological images of the resected tumor are compared with the maps of the electric field obtained with a simplified 3D model in Comsol Multiphysics v 4.3.ResultsThe results of the clinical case demonstrated a reduced efficacy of the ECT treatment described. The proposed simple numerical model of the breast tumor located in a low conductive tissue suggests that this is due to the reduced electric field induced inside the tumor with such 5 electrodes placement. However, where the electric field is predicted higher than the reversible electroporation threshold (E>400 V/cm), also the histological images confirm the necrosis of the target with a good agreement between the modeled and clinical results.ConclusionsThe results suggest the dependence of the effectiveness of the treatment on the careful placement of the electrodes. A detailed planned procedure for the tumor analysis after the treatment is also needed in order to better correlate the single electrode positions and the histological images. Simulation models could be used to identify better electrodes configuration in planning the experimental protocol for ECT treatment of breast tumors.

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Section: Methodsmentioning

confidence: 99%

Modeling the positioning of single needle electrodes for the treatment of breast cancer in a clinical case

Denzi¹,

Strigari

Filippo³

et al. 2015

BioMed Eng OnLine

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“…A similar approach has also used in the grading of meat quality/fat content 23. More recently, other applications of bioimpedance have also been devised, including as a screening test for breast cancer (following up the work of the 1920s)46 and for the assessment of potentially malignant skin lesions 20. The technique of electrical impedance tomography, which is focused on image reconstruction, has also garnered considerable engineering interest over the past two decades and remains an intense area of research 5…”

Section: A Historical Perspective On Electricity In Biomedical Applicmentioning

confidence: 99%

Electrical impedance myography: Background, current state, and future directions

2009

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Electrical impedance myography (EIM) is a new non-invasive technique for the evaluation of neuromuscular disease that relies upon the application and measurement of high-frequency, lowintensity electrical current. EIM assesses disease-induced changes to muscle's normal composition and architecture, including myocyte atrophy and loss, edema, reinnervation, and the deposition of endomysial connective tissue and fat. With application of single-frequency electrical current, EIM can be used to help grade the severity of neuromuscular disease. Assessing electrical impedance across a spectrum of applied frequencies and with current flow at multiple orientations relative to the major muscle fiber direction can provide a more complete picture of muscle condition. EIM holds the promise of serving as an indicator of disease status, thus being useful in clinical trials work and in monitoring effectiveness of treatment in individual patients; ultimately, it may also find diagnostic application. Ongoing efforts have been focused on obtaining a deeper understanding of the basic mechanisms of impedance change, studying EIM in a variety of clinical contexts, and further refining the methods of EIM data acquisition and analysis. KeywordsElectrical impedance; muscle; neuromuscular disease; technique; anisotropy Electrical impedance myography (EIM) is a non-invasive, painless approach to muscle assessment based upon the application and measurement of high-frequency, low-intensity electrical current (Figure 1). In contrast to conventional needle electromyography (EMG) and most standard neurophysiological techniques, EIM does not focus on measuring the inherent electrical activity of the tissues. Rather, similar to diagnostic ultrasound, measurements are made over a small area of interest, with energy being applied to the body and the resultant surface patterns analyzed. Unlike ultrasound, however, in which energy is in the form of sound waves and the main interest is image reconstruction, in the case of EIM, electrical current is used and the output is a set of quantitative parameters describing the state of the muscle, with presently little emphasis on imaging (though this remains possible). Although still in a relatively early stage of development, EIM may have important clinical uses in the future, both as an indicator of neuromuscular disease status and as a diagnostic tool. This review will begin with a brief history of bioelectricity in neuromuscular disease, exploring why electrical impedance measurements have been essentially overlooked as a potential means of muscle assessment. It will then detail the basic concepts underlying impedance measurements in general and the substantial challenges of applying them effectively to muscle.Please address correspondence to: Seward B. Rutkove, MD, Beth Israel Deaconess Medical Center, Department of Neurology, 330 Brookline Avenue, Shapiro 810, Boston, MA 02215; srutkove@bidmc.harvard.edu, Tel: 617-667-8130; Fax: 617-667-8747. NIH Public Access It will then review the data tha...

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“…system over traditional X-ray mammography could make this technology a welcome addition to the tools available in the fight against breast cancer. Although much research has been devoted to both the theoretical and the practical developments of Electrical Impedance Mammography [6][7][8][9][10][11][12][13][14][15][16][17][18][19], to date, the technique has not reached clinical acceptance because of its sensitivity to measurement errors, high computational demands and practical issues: errors in electrode positions or boundary shape, high and uncontrollable contact impedance of the skin (variations of 20% or more).…”

Section: Introductionmentioning

confidence: 99%

A three-dimensional image reconstruction algorithm for electrical impedance tomography using planar electrode arrays

Perez

Pidcock

Sebu

2016

Inverse Problems in Science and Engineering

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We present a three-dimensional non-iterative reconstruction algorithm developed for conductivity imaging with real data collected on a planar rectangular array of electrodes. Such an electrode configuration as well as the proposed imaging technique are intended to be used for breast cancer detection. The algorithm is based on linearizing the conductivity about a constant value and allows real-time reconstructions. The performance of the algorithm was tested on numerically simulated data and we successfully detected small inclusions with conductivities three or four times the background lying beneath the data collection surface. The results were fairly stable with respect to the noise level in the data and displayed very good spatial resolution in the plane of electrodes.

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Dual-frequency electrical impedance mammography for the diagnosis of non-malignant breast disease

Cited by 28 publications

References 5 publications

Modeling the positioning of single needle electrodes for the treatment of breast cancer in a clinical case

Modeling the positioning of single needle electrodes for the treatment of breast cancer in a clinical case

Electrical impedance myography: Background, current state, and future directions

A three-dimensional image reconstruction algorithm for electrical impedance tomography using planar electrode arrays

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