We describe a method by which the reactions in a metabolic system may be grouped hierarchically into sets of modules to form a metabolic reaction tree. In contrast to previous approaches, the method described here takes into account the fact that, in a viable network, reactions must be capable of sustaining a steady-state flux. In order to achieve this decomposition we introduce a new concept--the reaction correlation coefficient, phi, and show that this is a logical extension of the concept of enzyme (or reaction) subsets. In addition to their application to modular decomposition, reaction correlation coefficients have a number of other interesting properties, including a convenient means for identifying disconnected subnetworks in a system and potential applications to metabolic engineering. The method computes reaction correlation coefficients from an orthonormal basis of the null-space of the stoichiometry matrix. We show that reaction correlation coefficients are uniquely defined, even though the basis of the null-space is not. Once a complete set of reaction correlation coefficients is calculated, a metabolic reaction tree can be determined through the application of standard programming techniques. Computation of the reaction correlation coefficients, and the subsequent construction of the metabolic reaction tree is readily achievable for genome-scale models using a commodity desk-top PC.
We present a 3D reconstruction algorithm with sparsity constraints for electrical impedance tomography (EIT). EIT is the inverse problem of determining the distribution of conductivity in the interior of an object from simultaneous measurements of currents and voltages on its boundary. The feasibility of the sparsity reconstruction approach is tested with real data obtained from a new planar EIT device developed at the The complete electrode model is adapted for the given device to handle incomplete measurements and the inhomogeneities of the conductivity are a priori assumed to be sparse with respect to a certain basis. This prior information is incorporated into a Tikhonov-type functional by including a sparsity-promoting 1 -regularization term. The functional is minimized with an iterative soft shrinkage-type algorithm.
This study investigates the closed-loop performance of the basic current feedback operational amplifier (CFOA), with particular emphasis on its dynamic response. It also focuses on the design, performance and advantages of the CFOA in its ability to provide a substantially constant closed-loop bandwidth for closed-loop voltage gain. Furthermore, an improved CFOA with wide bandwidth and common-mode-rejection ratio (CMRR) performance is also presented. The design presented in this article uses a bootstrapping technique with Quasi-Darlington in the input stage to reduce the influence of the Early effect which results in improved performance. Another advantage of this design is that the inverting input impedance is reduced significantly, which leads to further improvement in bandwidth and CMRR.
We present an image reconstruction algorithm for the Inverse Conductivity Problem based on reformulating the problem in terms of integral equations. We use as data the values of injected electric currents and of the corresponding induced boundary potentials, as well as the boundary values of the electrical conductivity.We have used a priori information to find a regularized conductivity distribution by first solving a Fredholm integral equation of the second kind for the Laplacian of the potential, and then by solving a first order partial differential equation for the regularized conductivity itself. Many of the calculations involved in the method can be achieved analytically using the eigenfunctions of an integral operator defined in the paper.
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