Dual Extracts of Star Fruit Leaves and Toddalia accuelata Leaves as Antiobesity in Rats

The Effects of Leaves Extract of Toddalia aculeata on Body Weight, Body Mass Index, Body Fat Content and Resistive Index in Male Rats with High-Fat Diet

“…34 Regarding the BMI reduction, the administration of 400 and 800 mg/ kg BW TAE was better than the administration of 200 mg/kg BW TAE and 2.98 µg/kg BW pure dictamine. These findings are in accordance with the previous study conducted by Sundari et al (2022) but the BMI reduction in our study (-6.65±3.3 g/cm 3 ) is lower than their result study (-14.51±0.65 g/cm 3 ). This discrepancy is probably caused by the role of apigenin and epicatechin compounds in the leaves extract of star fruits.…”

“…These findings suggest that TAE administration potentially becomes an alternative therapy to reduce BW for obesity management. Our study is different from a previous study conducted by Sundari et al (2022) that TAE administration is used for obesity treatment instead of obesity prevention. They combined 100 mg TAE with 750 mg star fruit extract and which significantly reduced BW from 220.60±9.27 g to 150.80±4.70 g. Although TAE contains 20±0.5 µM dictamine and has low cytotoxicity with 245.22 g/mL IC 50 value, the action mechanism underlying the effect of TAE administration on BW reduction remains unknown.…”

“…They combined 100 mg TAE with 750 mg star fruit extract and which significantly reduced BW from 220.60±9.27 g to 150.80±4.70 g. Although TAE contains 20±0.5 µM dictamine and has low cytotoxicity with 245.22 g/mL IC 50 value, the action mechanism underlying the effect of TAE administration on BW reduction remains unknown. 27 In contrast, another research study reported that administration of 200 and 400 mg/kg BW leaves extracts from T. aculeata significantly reduced serum levels of total cholesterol, triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) in rats with hyperlipidemia but the researchers did not identify their active compounds and reported BW reduction. 34 Regarding the BMI reduction, the administration of 400 and 800 mg/ kg BW TAE was better than the administration of 200 mg/kg BW TAE and 2.98 µg/kg BW pure dictamine.…”

“…A high-fat diet (HFD) in this study was adopted from the Sundari et al (2022) research study 27 with slight modification. Each kg of HFD consisted of 400 mg Broiler-2 feed (Japfa Comfeed, Indonesia), 6 duck egg yolks, 6 dried organs of chicken liver, and 100 ml lard.…”

“…A recent study has reported that a combination of leaves extracts of T. aculeata and star fruit significantly reduced BW (-69.8 g), BMI (-14.51 ± 0.65 g), and BFC (-13.95 ± 0.63 g/cm) compared to the control group in rats with obesity. 27 Therefore, the objective of this study was to investigate the effects of TAE administration on BW, BMI, BFC, and RI in rats with HFD.…”