Dual Effects of Isoflurane on Neuronal Proliferation/Differentiation

Velly, Lionel; Mantz, Jean; Bruder, Nicolas

doi:10.1097/aln.0b013e3182833fe9

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Isoflurane has lasting and severe effects on cognitive function. In particular, it can affect learning and memory function in sea horses (4,6). Isoflurane is a novel inhalation anesthetic, which is frequently used clinically (7).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway

Zhang

Zhang²,

Wang

et al. 2016

Molecular Medicine Reports

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Ginsenoside Rg1 is the primary active substance in ginseng, and it has multiple pharmacological actions. Investigations on the pharmacologic action of ginsenoside Rg1 have developed, with a particular focus on the regulation of metabolism. The present study hypothesized that the neuroprotective effects of ginsenoside Rg1 prevent cognitive impairment induced by isoflurane anesthesia via antioxidant, anti‑inflammatory and anti‑apoptotic effects, mediated by the phosphoinositide 3‑kinase (PI3K)/AKT/glycogen synthase kinase‑3β (GSK‑3β) pathway in aged rats. Sprague‑Dawley rats were divided into isoflurane and ginsenoside Rg1 groups and were treated with 20 mg/kg ginsenoside Rg1 for 7 days. Morris water maze was performed to analyze the cognitive function of the rats. Enzyme‑linked immunosorbent assays were used to analyze the levels of malondialdehyde, glutathione, interleukin (IL)‑1β, IL‑6 and caspase 3. The protein expression levels of AKT, GSK 3β, p21WAF1/CIP1 and p53 were measured using western blot analysis. Ginsenoside Rg1 significantly improved cognitive function, and exhibited antioxidant and anti‑inflammatory effects, demonstrating the neuroprotective effects of ginsenoside Rg1 against the effect of isoflurane anesthesia in the rats. In addition, ginsenoside Rg1 significantly reduced caspase‑3 activity, upregulated the expression of PI3K/AKT/GSK‑3β and downregulated the mRNA expression levels of p21WAF1/CIP1 and p53 in the aged rats exposed to isoflurane anesthesia. The data obtained in the present study provided evidence that the neuroprotective effects of ginsenoside Rg1 prevented the cognitive impairment induced by isoflurane anesthesia via antioxidant, anti‑inflammatory and anti‑apoptotic effects, mediated by the PI3K/AKT/GSK‑3β pathway.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway

Zhang

Zhang²,

Wang

et al. 2016

Molecular Medicine Reports

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show abstract

“…Therefore, some ginsenosides as NMDA antagonists are promising therapeutic agents to treat neurodegenerative diseases. Isoflurane has lasting and severe effects on cognitive function, and it can affect learning and memory function in sea horses (Velly, Mantz, & Bruder, 2013;Wang et al, 2014). Some research have shown that ginsenoside Rg1 could attenuate the isoflurane-induced cognitive impairment.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

Xian

et al. 2022

Phytotherapy Research

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The nervous system is one of the most complex physiological systems, and central nervous system diseases (CNSDs) are serious diseases that affect human health. Ginseng (Panax L.), the root of Panax species, are famous Chinese herbs that have been used for various diseases in China, Japan, and Korea since ancient times, and remain a popular natural medicine used worldwide in modern times. Ginsenosides are the main active components of ginseng, and increasing evidence has demonstrated that ginsenosides can prevent CNSDs, including neurodegenerative diseases, memory and cognitive impairment, cerebral ischemia injury, depression, brain glioma, multiple sclerosis, which has been confirmed in numerous studies. Therefore, this review summarizes the potential pathways by which ginsenosides affect the pathogenesis of CNSDs mainly including antioxidant effects, anti-inflammatory effects, anti-apoptotic effects, and nerve protection, which provides novel ideas for the treatment of CNSDs.

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Dual effects of neuroprotection and neurotoxicity by general anesthetics on neural stem cells: Role of autophagy

Wang¹,

Wang²,

Wei³

2017

JESR

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General anesthetics (GAs) are widely used for various essential surgical or medical procedures. Recent studies implicate the GAs has dual effects of neuroprotection and neurotoxicity on neurogenesis with unclear mechanisms. This minireview summarizes recent studies on GAs mediated effects on neurogenesis and proposed mechanisms, with focus on autophagy regulation and intracellular calcium homeostasis.

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Dual Effects of Isoflurane on Neuronal Proliferation/Differentiation

Cited by 3 publications

References 12 publications

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

Dual effects of neuroprotection and neurotoxicity by general anesthetics on neural stem cells: Role of autophagy

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