Dual dynamic bonds enable biocompatible and tough hydrogels with fast self-recoverable, self-healable and injectable properties

Guo, Zanru; Gu, Hongjian; He, Yuan; Zhang, Yinshan; Xu, Wenyuan; Zhang, Jiali; Liu, Yongxin; Xiong, Lun; Chen, Ai-Xi; Feng, Yujun

doi:10.1016/j.cej.2020.124282

Cited by 52 publications

(47 citation statements)

References 48 publications

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“…For example, Guo et al [ 181 ] married acylhydrazone chemistry with transient hydrogen bonds to design tough injectable hydrogels. The gels were synthesized by free radical copolymerization of acrylamide and diacetoneacrylamide in the presence of adipic acid dihydrazide (ADH) and polyvinylpyrrolidone.…”

Section: Hydrogelsmentioning

confidence: 99%

Dually Crosslinked Polymer Networks Incorporating Dynamic Covalent Bonds

2021

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Covalent adaptable networks (CANs) are polymeric networks containing covalent crosslinks that are dynamic under specific conditions. In addition to possessing the malleability of thermoplastics and the dimensional stability of thermosets, CANs exhibit a unique combination of physical properties, including adaptability, self-healing, shape-memory, stimuli-responsiveness, and enhanced recyclability. The physical properties and the service conditions (such as temperature, pH, and humidity) of CANs are defined by the nature of their constituent dynamic covalent bonds (DCBs). In response to the increasing demand for more sophisticated and adaptable materials, the scientific community has identified dual dynamic networks (DDNs) as a promising new class of polymeric materials. By combining two (or more) distinct crosslinkers in one system, a material with tailored thermal, rheological, and mechanical properties can be designed. One remarkable ability of DDNs is their capacity to combine dimensional stability, bond dynamicity, and multi-responsiveness. This review aims to give an overview of the advances in the emerging field of DDNs with a special emphasis on their design, structure-property relationships, and applications. This review illustrates how DDNs offer many prospects that single (dynamic) networks cannot provide and highlights the challenges associated with their synthesis and characterization.

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Section: Hydrogelsmentioning

confidence: 99%

Dually Crosslinked Polymer Networks Incorporating Dynamic Covalent Bonds

2021

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“…Guo et al developed a physically chemically cross-linked hydrogel based on poly(acrylamide-co-diacetone acrylamide) (PAAm-co-DAAm), PVP, and adipic acid dihyadrazide (ADH). 129 PAAm-DAAm reacted with ADH to form hydrazone bonds (first cross-linking) and interacted with PVP by hydrogen bonds (second cross-linking). In this case, the combination of the two dynamic cross-linking moieties enhanced the mechanical properties of hydrogels (YM ∼ 350 kPa) compared with corresponding single cross-linked systems (YM ∼ 6 and 33 kPa).…”

Section: Dn As Injectable Hydrogelsmentioning

confidence: 99%

Trends in Double Networks as Bioprintable and Injectable Hydrogel Scaffolds for Tissue Regeneration

Aldana

Houben

Moroni

et al. 2021

ACS Biomater. Sci. Eng.

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“…Guo et al designed hydrogels based on the synergistic combination of acylhydrazone bonds and hydrogen bonding. [36] The reversible property of covalent dynamic acylhydrazone bonds can be achieved by the alternation of pH. Consequently, the tough hydrogels were injected upon acid and base stimuli.…”

Section: Gelation Before Injectionmentioning

confidence: 99%

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

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Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

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Dual dynamic bonds enable biocompatible and tough hydrogels with fast self-recoverable, self-healable and injectable properties

Cited by 52 publications

References 48 publications

Dually Crosslinked Polymer Networks Incorporating Dynamic Covalent Bonds

Dually Crosslinked Polymer Networks Incorporating Dynamic Covalent Bonds

Trends in Double Networks as Bioprintable and Injectable Hydrogel Scaffolds for Tissue Regeneration

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

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