Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu, Wenlin; Nie, Mingxi; Ke, Xiang; Luo, Jun; Li, Jianshu

doi:10.1002/mabi.202100109

Cited by 41 publications

(16 citation statements)

References 200 publications

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“…[196][197][198] In other words, double cross-linked hydrogels can combine the advantages of physical and chemical cross-linking methods to provide excellent features in terms of stability and mechanical strength. [199][200][201] Based on fascinating properties of the double cross-linked hydrogel systems, their research reports have attracted lots of attention. [202,203] Recently, Wen et al has prepared a double cross-linked TA-PU hydrogels.…”

Section: Double Cross-linkingmentioning

confidence: 99%

An Overview on Recent Progress of the Hydrogels: From Material Resources, Properties, to Functional Applications

Wang

Yang

et al. 2022

Macromol. Rapid Commun.

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Hydrogels, as the most typical elastomer materials with three-dimensional (3D) network structures, have attracted wide attention owing to their outstanding features in fields of sensitive stimulus response, low surface friction coefficient, good flexibility, and bio-compatibility. Because of numerous fresh polymer materials (or polymerization monomers), hydrogels with various structure diversities and excellent properties are emerging, and the development of hydrogels is very vigorous over the past decade. This review focuses on state-of-the-art advances, systematically reviews the recent progress on construction of novel hydrogels utilized several kinds of typical polymerization monomers, and explores the main chemical and physical cross-linking methods to develop the diversity of hydrogels. Following the aspects mentioned above, the classification and emerging applications of hydrogels, such as pH response, ionic response, electrical response, thermal response, biomolecular response, and gas response, are extensively summarized. Finally, this review is done with the promises and challenges for the future evolution of hydrogels and their biological applications.

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Section: Double Cross-linkingmentioning

confidence: 99%

An Overview on Recent Progress of the Hydrogels: From Material Resources, Properties, to Functional Applications

Wang

Yang

et al. 2022

Macromol. Rapid Commun.

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“…It can provide a better three-dimensional space for cell adhesion and growth by adjusting the polymer structure. [132] This property makes hydrogel an ideal platform for filling bone defects in non-load-bearing sites. For example, osteoblastsloaded hydrogels are implanted into the damaged part.…”

Section: Bone Repairmentioning

confidence: 99%

“…The microstructure of hydrogel is similar to that of bone. It can provide a better three‐dimensional space for cell adhesion and growth by adjusting the polymer structure [132] . This property makes hydrogel an ideal platform for filling bone defects in non‐load‐bearing sites.…”

Section: Current Situation Of Natural Polysaccharide‐based Dn Hydroge...mentioning

confidence: 99%

Recent Advances of Natural Polysaccharide‐based Double‐network Hydrogels for Tissue Repair

Wang

2022

Chemistry An Asian Journal

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Natural polysaccharide hydrogels have been extensively explored for many years due to their outstanding biocompatibility and biodegradability, which are very promising candidates as artificial soft materials for biomedical applications. However, their inferior mechanical performances greatly limited their applications. Introduction of double‐network (DN) structure has been well documented to be an efficient strategy for significant improvement of the mechanical property of hydrogels. Here, recent progress of natural polysaccharide‐based DN hydrogels is reviewed from the perspective of fundamental concepts on both design rationale and preparation strategies to biomedical application in tissue repair. Retrospect of the DN‐strengthened polysaccharide hydrogels can give a deep insight into the fundamental relationship of such bio‐based hydrogels among structural design, mechanical properties and practical demands, thereby prompting their translation to clinical application prospects.

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“…Hydrogels are a kind of soft materials with a hydrophilic three-dimensional network structure. Owing to their flexible, operable, highly swelling and soft features, hydrogels can be endowed with excellent mechanical property, ductility, and conductivity and are considered as an ideal material for flexible wearable devices. − However, due to the lack of an effective energy dissipation mechanism in the single-network hydrogel, most of the hydrogel-based flexible sensors have the problems of insufficient strength and toughness, which often leads to their damage under the action of strong external forces, thus greatly shortening their service lives. − Therefore, in order to improve the mechanical property and flexibility of hydrogel sensors, researchers proposed the double network (DN) hydrogels. The toughening mechanism of a DN structure is based on the sacrificial bond theory.…”

Section: Introductionmentioning

confidence: 99%

Tough, Self-Adhesive, Antibacterial, and Recyclable Supramolecular Double Network Flexible Hydrogel Sensor Based on PVA/Chitosan/Cyclodextrin

Fan

Zhao

Ling

et al. 2022

Ind. Eng. Chem. Res.

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Hydrogel-based flexible sensors have attracted extensive attention of researchers due to their great application potential in soft robots, electronic skin, motion monitoring, and disease diagnosis. However, it is still a challenge for hydrogel-based flexible sensors to be integrated with good mechanical performance, sensitivity, self-adhesion, fatigue resistance, antibacterial activity, and recyclability. Here, a novel supramolecular polyoxymethylene cross-linking agent (PCD-Fc-CHO) was designed and synthesized by the host−guest interaction between poly(β-cyclodextrin) and ferrocene. Then, a double network (DN) hydrogel was prepared by a PVA crystallization domain via the freezethaw cycle method (first network) and Schiff base between PCD-Fc-CHO and chitosan (second network). The obtained DN hydrogel was immersed in the NaCl solution to form a conductive DN hydrogel. The resulting hydrogel has excellent mechanical properties [tensile (314%, 0.5 MPa), compress (50%, 0.663 MPa)], good fatigue resistance (stretching and compressing cycles at least five times), reliable conductivity (2.48 S/m), high sensitivity [gauge factor (GF) = 4.87], antibacterial, and recyclable properties. In addition, an industrially produced and low-cost plant polyphenol, black wattle tannin, was used for the first time to give the hydrogel good adhesion and repeated adhesion (at least ten times). The obtained hydrogel can be used as a flexible strain sensor to monitor both large movements (bending finger, wrist, elbow, arm, and knee) and micromovements (talking, smiling, blinking, blowing, frowning, and drinking) with high sensitivity and stability. It is noteworthy that the reshaped hydrogel also exhibits sensitive sensing performance, indicating that the hydrogel can be recycled. This work expanded the strategy for the design and preparation of multi-functional DN hydrogels and promoted the application of wearable, highly sensitive, fatigue resistance, antibacterial, and green hydrogel sensors.

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Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Cited by 41 publications

References 200 publications

An Overview on Recent Progress of the Hydrogels: From Material Resources, Properties, to Functional Applications

An Overview on Recent Progress of the Hydrogels: From Material Resources, Properties, to Functional Applications

Recent Advances of Natural Polysaccharide‐based Double‐network Hydrogels for Tissue Repair

Tough, Self-Adhesive, Antibacterial, and Recyclable Supramolecular Double Network Flexible Hydrogel Sensor Based on PVA/Chitosan/Cyclodextrin

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