Dual crosslinked carboxymethyl sago pulp/pectin hydrogel beads as potential carrier for colon‐targeted drug delivery

Abstract

Carboxymethyl sago pulp (CMSP)/pectin hydrogel beads were synthesized by calcium crosslinking and further crosslinked by electron beam irradiation to form drug carrier for colon-targeted drug. Sphere-shaped CMSP/pectin 15%/5% hydrogel beads is able to stay intact for 24 h in swelling medium at pH 7.4. It shows pH-sensitive behavior as the swelling degree increases as pH increases. Fourier transform infrared spectroscopy analysis confirmed the absence of chemical interaction between hydrogel beads and diclofenac sodium. Differential scanning calorimetric and X-ray diffraction studies indicate the amorphous nature of entrapped diclofenac sodium. The drug encapsulation efficiency is up to about 50%. Less than 9% of drug has been released at pH 1.2 and the hydrogel beads sustain the drug release at pH 7.4 over 30 h. This shows the potential of CMSP/pectin hydrogel beads as carrier for colon-targeted drug.

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

“…In our approach, MTX was loaded onto CMC-GO by sonication in different ratios. CMC-GO offer abundant aromatic rings to adsorb MTX through π-π stacking and hydrophobic interactions [36]. As shown in Table 1, the drug-loading efficiency and encapsulation efficiency increases with the increasing MTX concentration, and achieves the highest amount of 39.33 ± 0.70%, 29.50 ± 0.53%, respectively, when the mass ratio of methotrexate to CMC-GO was 3:1.…”

The Effect of Citric Acid on Physicochemical Properties of Hydrophilic Carboxymethyl Starch-Based Films

“…Crosslinking of CMS has been performed to produce hydrogels for potential application in metal ions removal from water [3,4], as pharmaceutical gelling agent and emulsion stabilizer [5], tablet disintegrant [6], or for drug delivery systems [7,8]. The crosslinking agents were dichloroacetic acid [4,5], phosphorous oxychloride [3], epichlorohydrin [9], sodium trimetaphosphate [10], or polyfunctional carboxylic acids [11].…”

Citric Acid Cross‐Linking of Carboxymethyl Sago Starch Based Hydrogel for Controlled Release Application

“…Recently, the synthesis of composite hydrogel of CMSS with carboxymethyl sago pulp (CMSP) via electron beam irradiation (irradiation doses of 20–30 kGy) has been reported by Tan et al However, irradiation at high‐energy doses could result in the destruction of network structure . In comparison, chemically cross‐linked methylcellulose have been found to provide homogenous gel structure, whereas the radiation cross‐linked methylcellulose have been observed to cause less uniform cross‐linked films .…”