Dual antibacterial behavior of a curcumin–upconversion photodynamic nanosystem for efficient eradication of drug-resistant bacteria in a deep joint infection

Liu, Jiangjun; Yu, Ming-Chih; Zeng, Guobo; Cao, Jie; Wang, Yuanhe; Ding, Tao; Yang, Xu; Sun, Kang; Parvızı, Javad; Tian, Shaoqi

doi:10.1039/c8tb02493f

Cited by 33 publications

(23 citation statements)

References 36 publications

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“…Several kinds of UCNPs were applied to covert NIR to visible light or UV light for triggering PDT in tumor therapy or antibacterial application [29,30,31]. Gulzar et al synthesized a nanocomposite based on nanographene oxide-UCNPs-Ce6 as a theranostic platform for the upconversion luminescence imaging-guided PDT/PTT of cancer [29].…”

Section: Resultsmentioning

confidence: 99%

“…Such a near-infrared (NIR) triggered UCNPs-CPZ-PVP system significantly reduced the aggregation of CPZ and presented a high anti-infectious activity against multi-drug resistant bacteria (methicillin-resistant Staphylococcus aureus by 4.7 log and multi-drug resistant Escherichia coli by 2.1 log). Another study investigated the dual antibacterial behavior induced by the curcumin-UCNPs itself and induced by photodynamic therapy were demonstrated [31]. The results showed that nearly 100% methicillin-resistant Staphylococcus aureus was eradicated using curcumin-UCNPs under the NIR irradiation.…”

Section: Resultsmentioning

confidence: 99%

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Anti-Biofilm Property of Bioactive Upconversion Nanocomposites Containing Chlorin e6 against Periodontal Pathogens

Zhang

Ying

et al. 2019

Molecules

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Photodynamic therapy (PDT) based periodontal disease treatment has received extensive attention. However, the deep tissue location of periodontal plaque makes the conventional PDT encounter a bottleneck. Herein, upconversion fluorescent nanomaterial with near-infrared light excitation was introduced into the treatment of periodontal disease, overcoming the limited tissue penetration depth of visible light in PDT. Photosensitizer Ce6 molecules were combined with upconversion nanoparticles (UCNPs) NaYF4:Yb,Er with a novel strategy. The hydrophobic UCNPs were modified with amphiphilic silane, utilizing the hydrophobic chain of the silane to bind to the hydrophobic groups of the UCNPs through a hydrophobic-hydrophobic interaction, and the Ce6 molecules were loaded in this hydrophobic layer. This achieves both the conversion of the hydrophobic to the hydrophilic surface and the loading of the oily photosensitizer molecules. Because the excitation position of the Ce6 molecule is in the red region, Mn ions were doped to enhance red light, and thus the improved PDT function. This Ce6 loaded UCNPs composites with efficient red upconversion luminescence show remarkable bacteriological therapeutic effect on Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum and the corresponding biofilms under 980 nm irradiation, indicating a high application prospect in the treatment of periodontal diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Anti-Biofilm Property of Bioactive Upconversion Nanocomposites Containing Chlorin e6 against Periodontal Pathogens

Zhang

Ying

et al. 2019

Molecules

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“…In addition, besides coating on the surface of bone implants, the NIR light-responsive nanomaterials could also be injected into the knee joint for the clinical treatment of periprosthetic joint infection. Liu et al 93 has reported curcumin‑upconversion nanoparticles (curcumin-UCNPs) for the efficient eradication of drug-resistant bacteria in a deep joint infection by producing singlet oxygen under NIR light irradiation. Curcumin is an extract from the plant Curcuma longa , which has intrinsic antibacterial and anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…And the dispersion and antimicrobial of UNCP‐PSs can be improved with selected coating materials. Combining with the emitting light of UNCPs, in vivo therapeutic exercise can be designed with imaging tracking function, especially in the treatment of inflammation [83, 84] and cancer [54, 85] in deep tissues. Multifunctional UNCP‐PS with multi‐layer core–shell structure is a hot research topic, such as a composite nanoparticle with all magnetic resonance (MRI) imaging, upconversion luminescence (UCL) imaging, photodynamic/sonodynamic antibacterial and quaternised surface layer [56].…”

Section: Discussionmentioning

confidence: 99%

Recent advances in surface‐functionalised photosensitive antibacterials with synergistic effects

Liao

Wang

et al. 2019

Biosurface and Biotribology

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The alarm has been ringing over the gradually increasing drug-resistant bacteria, which calls for the development of safer antibacterial materials. Photosensitive antibacterials are considered as a promising alternative solution due to their unique light-activated antimicrobial mechanism, which in-situ produces highly reactive oxygen species on the multiple and variable active sites for the inactivation of various microbes. However, there are some factors, including phototoxicity, oxygen consumption and the risk of microbial contamination, greatly limit the efficiency and application of photosensitisers (PSs) in practical biomedical applications. Some studies have explored the synergistic effects of PSs by antibiotics, photothermal agents, antibacterial nanoparticles and biofilm-disrupting enzymes. Moreover, novel synergistic methods for improving the antibacterial ability of PSs under low-energy irradiation, hypoxia conditions and dull conditions, have been rarely reviewed yet. Herein, the authors summarised some synergistic methods and related applications of surface-functionalised photosensitive antimicrobials, which were prepared with organic antimicrobial materials, superhydrophobic surfaces, upconversion nanoparticles and energy storage structures in recent years. Finally, the authors presented the advantages and challenges of these synergistic mechanisms, and further analysed the development trend and application prospects of the surface-functionalised photosensitive antibacterials in biomedical fields. 2 Photosensitive antibacterials with synergistic effects 2.1 Organic antibacterial materials and photosensitive antibacterials Compensating the defects of PSs through the synergistic effect of antibacterial materials is a convenient method. Organic antibacterial agents can be combined with PSs by chemical bonds to change the water solubility and the molecular weight of PSs while exerting synergistic antibacterial action. The following Biosurface and Biotribology

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Dual antibacterial behavior of a curcumin–upconversion photodynamic nanosystem for efficient eradication of drug-resistant bacteria in a deep joint infection

Abstract: The curcumin–upconversion photodynamic nanosystem exhibits dual antibacterial behavior for MRSA-induced periprosthetic joint infection under NIR irradiation.

Cited by 33 publications

References 36 publications

Anti-Biofilm Property of Bioactive Upconversion Nanocomposites Containing Chlorin e6 against Periodontal Pathogens

Anti-Biofilm Property of Bioactive Upconversion Nanocomposites Containing Chlorin e6 against Periodontal Pathogens

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Recent advances in surface‐functionalised photosensitive antibacterials with synergistic effects

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