Dry Powder Coating of Pellets with Micronized Eudragit<sup>®</sup>RS for Extended Drug Release

Pearnchob, Nantharat; Bodmeier, Roland

doi:10.1023/b:pham.0000008044.78968.81

Cited by 46 publications

(12 citation statements)

References 7 publications

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“…Various commercially available polymers are in the form of dry powder, aqueous dispersion, or as organic solution [3]. They are mainly used as film formers in application for functional pharmaceutical coatings for controlling the release of drugs [4] and as matrix formers in granulation techniques [5]. Eudragit ® acrylic resins are harmless and inert compounds, not absorbed in the GIT and are resistant to body fluids.…”

Section: Introductionmentioning

confidence: 99%

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

Gupta¹,

Kumar²,

Sachan³

2015

PHARMSCI

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Drugs with lower bioavailability need repeated dosing to reach the minimum effective therapeutic concentration in plasma. In order to retain the drug in upper part of gastro intestinal tract (GIT) which is the major absorption window for majority of drugs and also to have localized effect many advances in drug delivery were made. Researchers mainly emphasize on to get patient compliance by formulating single dose, targeted and minimal side effects dosage form. The design must give constant drug release for longer time period that could be achieved through proper selection of polymers. These approaches in dosage design may also be advantageous for local action, to prevent drug degradation, delivery of gastro-irritant, narrow absorption window drugs and to get pH dependent release throughout the GIT. Polymethacrylate polymers in different ratios are available for the above objective as they are inert materials, could stay for longer time and are resistant to body fluids. This review also discusses the physicochemical properties of different available grades along with their glass transition temperatures (Tg).

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Section: Introductionmentioning

confidence: 99%

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

Gupta¹,

Kumar²,

Sachan³

2015

PHARMSCI

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“…Figure 6 shows the dissolution profile of AAP from samples produced by one-step or two-step addition of CW (Rp. 8,9). The one-step processing was performed that all components was added and processed in the mechanofusion for 10 min at the specified condition after pre-processing.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, many solventless coating technologies have been reported 4 . Concerning dry powder coating, some researchers reported a system in which the coating polymer and the binder/plasticizer solution are fed directly to the core particle [5][6][7][8][9] . In such a system, a small amount of water and a curing step are required to promote film…”

Section: Introductionmentioning

confidence: 99%

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Hoashi¹,

Tozuka²,

Takeuchi³

2012

Drug Development and Industrial Pharmacy

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“…This product possessed controlled-release properties owing to its multi-layer coating (3). Additionally, Pearnchob and Bodmeier prepared a granule with controlled-release properties using a fine powder coating of methacrylate copolymers and a Wurster fluidized bed coating apparatus (4). The disadvantages of these two approaches include the need for extended periods of heat treatment and the use of liquid plasticizers.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Controlled-Release Fine Particles Using a Dry Coating Method

et al. 2016

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Abstract. Wet coating methods use organic solvents to prepare layered particles that provide controlledrelease medications. However, this approach has disadvantages in that it can cause particle agglomeration, reduce pharmaceutical stability, and leave residual organic solvents. We used a dry coating method to overcome these issues. Fine particles (less than 50 μm in diameter) of controlled-release theophylline were created using theophylline (TP; model drug), polyethylene glycol 20,000 (PEG; drug fixative), hydrogenated castor oil (HCO; controlled-release material), hydrogenated rapeseed oil (HRSO; controlledrelease material), and cornstarch (CS; core particle). An ultrahigh-speed mixer was employed to mix TP and CS for 5 min at 28,000 rpm. Subsequent addition of PEG produced single-core particles with a drug reservoir coating. Addition of HCO and HRSO to these particles produced a controlled-release layer on their surface, resulting in less than 10% TP dissolution after 8 h. We successfully demonstrated that this dry coating method could be used to coat 16-μm CS particles with a drug reservoir layer and a controlledrelease layer, producing multi-layer coated single-core particles that were less than 50 μm in diameter. These can be used to prepare controlled-release tablets, capsules, and orally disintegrating tablets.

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Dry Powder Coating of Pellets with Micronized Eudragit^®RS for Extended Drug Release

Abstract: This novel coating technique avoids the use of organic polymer solutions or latex dispersions, has short processing times, and results in stable extended-release profiles.

Cited by 46 publications

References 7 publications

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Preparation of Controlled-Release Fine Particles Using a Dry Coating Method

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Dry Powder Coating of Pellets with Micronized Eudragit®RS for Extended Drug Release

Abstract: This novel coating technique avoids the use of organic polymer solutions or latex dispersions, has short processing times, and results in stable extended-release profiles.

Cited by 46 publications

References 7 publications

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Preparation of Controlled-Release Fine Particles Using a Dry Coating Method

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Product

Resources

About

Dry Powder Coating of Pellets with Micronized Eudragit^®RS for Extended Drug Release