Preparation of Controlled-Release Fine Particles Using a Dry Coating Method

Abstract

Abstract. Wet coating methods use organic solvents to prepare layered particles that provide controlledrelease medications. However, this approach has disadvantages in that it can cause particle agglomeration, reduce pharmaceutical stability, and leave residual organic solvents. We used a dry coating method to overcome these issues. Fine particles (less than 50 μm in diameter) of controlled-release theophylline were created using theophylline (TP; model drug), polyethylene glycol 20,000 (PEG; drug fixative), hydrogenated castor oil (HCO; controlled-release material), hydrogenated rapeseed oil (HRSO; controlledrelease material), and cornstarch (CS; core particle). An ultrahigh-speed mixer was employed to mix TP and CS for 5 min at 28,000 rpm. Subsequent addition of PEG produced single-core particles with a drug reservoir coating. Addition of HCO and HRSO to these particles produced a controlled-release layer on their surface, resulting in less than 10% TP dissolution after 8 h. We successfully demonstrated that this dry coating method could be used to coat 16-μm CS particles with a drug reservoir layer and a controlledrelease layer, producing multi-layer coated single-core particles that were less than 50 μm in diameter. These can be used to prepare controlled-release tablets, capsules, and orally disintegrating tablets.

<p>Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin</p>

“…Coating technologies and nanoparticles are always used to produce the function preparations with ability of controlled 23,24 and target release 25 and to improve the palatability of the poor-tasting drugs. 26 However, the single-coating granules, tablets, capsules, and other formulations will be chewed up by Thus, the coated drugs will be released and attached with the taste buds of animal mouth.…”

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

“…Moreover, further improved coating performance was achieved with the use of porous nanoparticle agglomerates as guest particles, due to the formation of fine fragments under mechanical stress (37). In addition, in another study, an ultrahigh-speed mixer was used to achieve coating for cores as small as 16μm, and multi-layer coated single-core particles with less than 50μm in diameter were finally prepared (38). More specifically, the cornstarch core was coated with a drug reservoir layer and a controlled-release layer where PEG 20,000 worked as drug fixative, while hydrogenated castor oil and hydrogenated rapeseed oil played a role in controlling drug release.…”

“…More specifically, the cornstarch core was coated with a drug reservoir layer and a controlled-release layer where PEG 20,000 worked as drug fixative, while hydrogenated castor oil and hydrogenated rapeseed oil played a role in controlling drug release. Evidence indicated that the multi-layer coated single-core particles produced could be applied in sustained-release systems (38).…”

Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

“…High surface area of FiUlFiPs is reasoning for receiving interest 1,2,4 . Researchers (scientists and engineers) in pharmaceutical sectors working extensively in finding applications and taking advantage of many worthy properties and new functionalities attributed to FiUlFiPs, as drug delivery system/carriers 1,2,5 .…”