Drug utilization pattern in pregnancy at a tertiary care hospital in Puducherry: a cross sectional observational study

Selvaraj, Nitya; Sekar, A.; Gandhi, Ramya; Jayabalan, Nalinidevi; Ganesan, Suganeswari; Mohammad, Meher Ali Raja

doi:10.18203/2319-2003.ijbcp20181632

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…However, the use of medications is sometimes mandatory in the treatment of women of reproductive age, breast feeding and during pregnancy. 21 In our study a total of 168 participants were interviewed; of whom, 81(51.9%) patients were age between 20-35 years were higher than consistent with the study done at a tertiary care hospital in Puducherry 22 which revealed among 365 pregnant women attending antenatal clinic, 43% were in age group of 22 to 25 years which represents the normal reproductive age group. This difference was due to participants age classification category.…”

Section: Discussionsupporting

confidence: 66%

Drug usage pattern and potential teratogenesity risk among pregnant women attending maternal and child health clinic of Mettu Karl Referral Hospital, South Western, Ethiopia: a cross sectional study, 2021

Bereda¹,

Bereda²

2021

IPCB

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Introduction: Physiological alterations during pregnancy as well as the bio- conversion of compounds can significantly influence the teratogenic effects of drugs and chemicals by affecting absorption, body distribution, the active form(s), and excretion of the compound. Certain medications may cause harm to the foetus due to their potential teratogenic effects and the physiological adjustments occurring in the mother during pregnancy. Prescription of drug used by pregnant women should be viewed as one of a public health issue. This study aware health care workers on harmful drugs prescription to pregnant women and helps in understanding the type of medication used during pregnancy and safety of drugs used during pregnancy, thereupon this study was ascertain drug usage pattern and potential teratogenicity risk among pregnant women attending maternal and child health clinic of Mettu Karl Referral Hospital. Methods: A hospital-based cross-sectional study design was carried out from April 13/2021 to June 15/2021. Data was collected through employing semi-structured questioner, and then the collected data was cleared, coded and analyzed by statistical packages for social sciences 25.0 version statistical software. Descriptive statistics were used to describe the data. P value <0.05 was considered as a cut point for statistical significance in the final model. Results: A total of 156 participants were interviewed of whom, 81(51.9%) pregnant women were age between 20-35 years old and a majority 113(72.4%) of them were married. Among medical condition majority 40(25.6%) of the participants had peptic ulcer disease and 26(16.7%) urinary tract infections followed by 20(12.8%) acute illness and 12(7.7%) hyperemesis. Among the total drug prescribed for pregnant women 30(19.2%) FDA category C was the common followed by 29 (186%) FDA category B and 26(16.7%) FDA category D. Only 10(6.4%) of prescribed drug were FDA category X. Pregnant women whose age >35 years (AOR=4.05, 95%CI:1.274-1.903; p=0.001), urban residents (AOR=2.72, 95%CI:2.524-3.927; p=0.035), and pregnant women during second trimester (AOR=1.79, 95%CI:3.926-9.406; p=0.013) were significantly associated with MCH follow up. Conclusion and recommendation: From the drug prescribed, majority of pregnant women were taken antibiotics followed by 18(11.5%) NSAID, iron sulfate, and proton pump inhibitors. Among the dosage form, above half of the participants were taken the tablet dosage form followed by capsule and gels dosage form. Health care workers should have to brought good care for pregnant women, since they perhaps vulnerable to drug teratogenesity

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Section: Discussionsupporting

confidence: 66%

Drug usage pattern and potential teratogenesity risk among pregnant women attending maternal and child health clinic of Mettu Karl Referral Hospital, South Western, Ethiopia: a cross sectional study, 2021

Bereda¹,

Bereda²

2021

IPCB

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“…Whereas, results of study conducted in Puducherry showed that 3.6% of third trimester women were prescribed with category B drugs. 25 In the current study, category D drugs were prescribed in 1.05% of pregnant women whereas higher prevalence of prescription (9.3%) of category D drugs was reported in other study in Ethiopia. 26 Results of the current study showed that diclofenac belonged to category D and C in 1.78% and 4.2% of cases respectively.…”

Section: Discussioncontrasting

confidence: 58%

Assessment of Drug prescription Pattern in pregnancy in A Tertiary Care Hospital: A Prospective Study

Vafaeerokh

Sheriff

2022

Int J Life Sci Pharm Res

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Pregnancy is a special physiological condition and managing medical conditions during pregnancy is a challenge due to the teratogenic potential of many drugs. This cross-sectional prospective study was conducted for a period of 6 months to describe the prescription pattern and risk categorization of drugs among pregnant inpatients in a tertiary care hospital. Pregnant inpatients of OBG ward in any trimester who were prescribed with at least one drug were included. Demographic details and list of prescribed drugs were collected from medical records of patients. The drugs prescribed were grouped according to their pharmacological classes and US FDA pregnancy risk classification. Prescription pattern was assessed using WHO core prescribing indicators. A total of 951 drugs comprising 34 different drugs were prescribed for 420 pregnant women. The average number of drugs prescribed per encounter was 2.3 ± 0.9 (SD). Anti- anemic/vitamin and mineral supplements (288, 30.3%), followed by antibiotics (142, 14.93%) and antihypertensive drugs (127, 13.35%) were the most commonly prescribed classes of drugs. As per FDA Drug Risk Category, most of prescribed drugs belonged to category B (42.26%) and category A (32.9%) followed by category C (17%), category D (1.05%) and category X (0.84%). It was found that the overall prescription pattern of drugs among pregnant inpatients was safe and rational since the majority of prescribed drugs fell under category A and B pregnancy. Continuous drug utilization evaluation in this population and interaction of clinical pharmacist with healthcare team is crucial to have rational and safe prescription of drugs among hospitalized pregnant women.

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“…Similar kind of results were found in our study population i.e., 15.7 % of prescriptions were of folic acid. In another study conducted by Selvaraj et al [12] the most commonly prescribed drugs in 1 st , 2 nd , and 3 rd trimester were iron, calcium and folic acid which we can see in our results too i.e., 15.2 % calcium and 7.1 % ferrous fumarate were prescribed.…”

Section: Table 3: Ddd/100 Bed D Of Fda Category Drugs (A and B) Used ...supporting

confidence: 67%

Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital

Emmanuel¹,

Nair²,

Mv³

et al. 2023

IJPS

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A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.

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Drug utilization pattern in pregnancy at a tertiary care hospital in Puducherry: a cross sectional observational study

Cited by 5 publications

References 12 publications

Drug usage pattern and potential teratogenesity risk among pregnant women attending maternal and child health clinic of Mettu Karl Referral Hospital, South Western, Ethiopia: a cross sectional study, 2021

Drug usage pattern and potential teratogenesity risk among pregnant women attending maternal and child health clinic of Mettu Karl Referral Hospital, South Western, Ethiopia: a cross sectional study, 2021

Assessment of Drug prescription Pattern in pregnancy in A Tertiary Care Hospital: A Prospective Study

Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital

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