Drug treatment of experimentalCapillaria hepatica infection in mice

Abstract

This report presents the results obtained using 14 anthelmintic compounds that were tested in experimental white mice of the Swiss-Webster strain for their action against Capilaria hepatica. Four of the drugs effectively prevented deposition of C. hepatica ova in mouse liver. The doses at which these four drugs prevented greater than 99% of egg deposition were: albendazole, 30 mg/kg; febantel, 30 mg/kg; mebendazole, 3.13 mg/kg; and oxfendazole, 12.5 mg/kg. Of these, mebendazole is the only agent for which the application of five daily doses of 3.13 mg/kg lay within the dose range recommended for man.

Hepatic capillariasis in children: report of 3 cases in Brazil.

“…Thus, these investigators concluded that mebendazole may continue to be the drug of choice for the treatment of human capillariasis. 12 No side effects of the drugs and doses used were detected in the 3 patients in this study.…”

“…Humans become infected by ingesting mature embryonated eggs in food or dirt. [1][2][3][4][5][6][7][8][9][10]12,13 These worms are therefore considered to be geohelminths. 13 Infection occurs after the ingestion of embryonated (infecting) eggs.…”

“…Cheetham and Markus, in an experimental study in mice, demonstrated that the separate use of albendazole, febantel, mebendazole, and oxfendazole prevented ovipositing by C. hepatica by more than 99%. 12 However, mebendazole was the only agent for which the dose used coincided with the therapeutic dose recommended for humans. Thus, these investigators concluded that mebendazole may continue to be the drug of choice for the treatment of human capillariasis.…”

Persistent febrile hepatomegaly with eosinophilia due to hepatic capillariasis in Central China

“…Thus, it may be necessary to use corticosteroids to reduce the inflammatory response (Pereira and Franca, 1983), as was done here for our patient. However, the results of an experimental study in mice demonstrated that albendazole prevented ovipositing by C. hepatica by more than 99% (Cheetham and Markus, 1991). So, albendazole may continue to be the drug of choice for the treatment of human capillariasis.…”

STUDY OF THE PREVALENCE OF Capillaria hepatica IN HUMANS AND RODENTS IN AN URBAN AREA OF THE CITY OF PORTO VELHO, RONDÔNIA, BRAZIL

“…No consensus exists on the treatment of this disease. CHEETHAM & MARKUS 6 used mebendazole and albendazole in an experimental rat model and showed that these drugs prevented oviposition in the hepatic parenchyma. EL GEBALY et al.…”