This report presents the results obtained using 14 anthelmintic compounds that were tested in experimental white mice of the Swiss-Webster strain for their action against Capilaria hepatica. Four of the drugs effectively prevented deposition of C. hepatica ova in mouse liver. The doses at which these four drugs prevented greater than 99% of egg deposition were: albendazole, 30 mg/kg; febantel, 30 mg/kg; mebendazole, 3.13 mg/kg; and oxfendazole, 12.5 mg/kg. Of these, mebendazole is the only agent for which the application of five daily doses of 3.13 mg/kg lay within the dose range recommended for man.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.