Drug-induced pemphigus

Brenner, Sarah; Goldberg, Ilan

doi:10.1016/j.clindermatol.2011.01.016

Cited by 81 publications

(71 citation statements)

References 26 publications

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“…En effet, ces plantes traditionnelles pourraient contenir des dérivés thiolés dont le rôle inducteur est bien connu [17]. Ceci pourrait aussi expliqué que certains patients présentaient en plus des bulles classiques de …”

Section: Discussionunclassified

Epidemiological and clinical aspects of pemphigus in Senegal

Diallo¹,

Diatta²,

Diop³

et al. 2017

Our Dermatol Online

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Background: The purpose of this study was to specify the epidemiological and clinical characteristics of pemphigus in the Department of Dermatology of the University Hospital of Dakar. Patients and Methodology: All medical records of patients seen for pemphigus in our department over a 11-year period were analyzed retrospectively. Results: We collected 105 cases of pemphigus, corresponding to a frequency of 10 cases/year and a hospital prevalence of 2.7%. Thus, pemphigus held the second rank of blistering autoimmune bullous diseases after bullous pemphigoid. The mean age of patients was 47.62 years and the age group [40-59 years] was predominantly affected (28 cases; 45 %). There were 41 femeles and 21 men (F/M ratio: 2). We did not find an endemic focus in our country. Clinical forms were dominated by pemphigus foliaceus (30 cases; 48.5 %), followed by pemphigus vulguaris (19 cases; 30.6 %) and finally by pemphigus erythematosus (13 cases; 21%). In 16 cases (25 %), the pemphigus had begun after the consumption of a traditional medicinal plant (8 cases). An associated toxidermia was found in12 cases. Pruritus was present in 43 patients (69.35%). Discussion: In Senegal, pemphigus are common diseases, but without however an endemic focuc. They occur in young women, with a predominance of superficial forms, especially pemphigus foliaceus. The presence of pruritus and associated toxidermia to traditional medicinal plants are common.

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Section: Discussionunclassified

Epidemiological and clinical aspects of pemphigus in Senegal

Diallo¹,

Diatta²,

Diop³

et al. 2017

Our Dermatol Online

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“…Calcium channel blockers can cause pemphigus because calcium is needed for the activity of enzymes that have roles in keratogenesis, and desmogleins are calcium dependent. [39][40][41][42][43] Penicillamine the prototype of thiol drugs was the first drug reported to induce pemphigus. It has been estimated that 7% of patients taking this drug for at least 6 months develop pemphigus.…”

Section: Discussionmentioning

confidence: 99%

Cicatricial changes in ocular pemphigus

Chirinos-Saldaña

Zuñiga-Gonzalez

Hernández-Camarena

et al. 2014

Eye

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“…Various environmental factors such as drugs (captopril, penicillamine), infections (herpes simplex virus, Epstein-Barr virus, etc. ), pesticides, ultraviolet radiation (UVR), ionizan radiation, thermal burns, stress and food containing an allium, phenol, thiol, or urushiol have been reported to trigger PV [10,13,34].…”

Section: Pemphigus Vulgarismentioning

confidence: 99%

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Kılıç¹

2018

Autoimmune Bullous Diseases

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Pemphigus is a group of autoimmune blistering disorders associated with autoantibodies against the keratinocyte cell surface. Pemphigus has three major variants: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP) which all have further subtypes. The variants of pemphigus are classified depending upon the clinical and histological features, immunofluorescence staining pattern, and autoantibody profile of the disease. The onset and course of pemphigus appear on the basis of interaction between genetic predisposition and various triggering factors. Pemphigus vulgaris is the most commonly seen and representative clinical form of pemphigus. Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis. As though some pemphigus variants, particularly pemphigus vulgaris and paraneoplastic pemphigus, have a mortality risk, early diagnosis is necessary and onset of treatment should be promptly initiated. In this chapter, firstly, classification of pemphigus is described. After then, clinical features, histopathological and immunopathological findings, target antigens, etiopathogenesis and comorbidities of each pemphigus variant are discussed briefly.Keywords: pemphigus, pemphigus variants, clinical manifestations, pathogenesis, histopathology, immunopathology IntroductionPemphigus is a distinct organ-specific autoimmune blistering disorder involving skin and mucous membranes associated with autoantibodies directed against desmosomes-intercellular adhesive molecule complex localized on the keratinocyte cell surface [1][2][3][4].© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Pemphigus has three major variants, which are classified depending on the basis of the clinical, histological features, immunofluorescence staining pattern and autoantibody profile of the disease including pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP), which all have further subtypes. Less frequently seen and newer variants of pemphigus include IgA pemphigus (IGAP) and pemphigus herpetiformis (PH) [1-6].The term "pemphigus" origins from the Greek word "pemphix", which has a meaning of "blister" [1]. It is a chronic potentially life-threating bullous disorder if not treated on time [4,7,8]. The phenotypes of pemphigus represent a complex spectrum with multiple genetic and environmental factors playing a role in disease pathogenesis [9,10].Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis of the disease. The best site for the cutaneous biopsy for the appropriate histopathological examination is a fresh (< 24 h) small vesicle or 1/3 of the peripheral portion of the blister including the perilesional normal appearing s...

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Drug-induced pemphigus

Cited by 81 publications

References 26 publications

Epidemiological and clinical aspects of pemphigus in Senegal

Epidemiological and clinical aspects of pemphigus in Senegal

Cicatricial changes in ocular pemphigus

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

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