Drug-induced hair colour changes

Bublin, J. G.; Thompson, Dennis F.

doi:10.1111/j.1365-2710.1992.tb01307.x

Cited by 27 publications

(21 citation statements)

References 30 publications

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“…This is slightly earlier than in previous reports which supported that drug-induced pigmentation of hair occurs after 3-12 months of treatment [4].…”

Section: Introductioncontrasting

confidence: 52%

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Hair Repigmentation in a Hepatitis C Patient Treated with Interferon and Ribavirin

Kavak

Akcan²,

Korkmaz

2005

Dermatology

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“…This is slightly earlier than in previous reports which supported that drug-induced pigmentation of hair occurs after 3-12 months of treatment [4].…”

Section: Introductioncontrasting

confidence: 52%

“…Hypopigmentation of hair is a well-known side effect of chloroquine and mephenesin [4,5]. Drug-induced repigmentation of hair could occur with many drugs such as verapamil and carbidopa [6,7].…”

mentioning

confidence: 99%

Hair Repigmentation in a Hepatitis C Patient Treated with Interferon and Ribavirin

Kavak

Akcan²,

Korkmaz

2005

Dermatology

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“…This finding also suggests that the cytokine milieu may be alterable to provide a more permissive microenvironment for melanocyte migration and activation. Temporary hair darkening has also been reported after drug ingestion including high doses of para‐aminobenzoic acid [94], though it is not clear whether the increased pigmentation here was directly related with enhanced hair bulb melanocyte activity.…”

Section: The Ageing Hair Follicle Pigmentary Unitmentioning

confidence: 97%

Human hair pigmentation – biological aspects

Tobin¹

2008

Intern J of Cosmetic Sci

105

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Synopsis Skin and hair colour contribute significantly to our overall visual appearance and to social/sexual communication. Despite their shared origins in the embryologic neural crest, the hair follicle and epidermal pigmentary units occupy distinct, although open, cutaneous compartments. They can be distinguished principally on the basis of the former’s stringent coupling to the hair growth cycle compared with the latter’s continuous melanogenesis. The biosynthesis of melanin and its subsequent transfer from melanocyte to hair bulb keratinocytes depend on the availability of melanin precursors and on a raft of signal transduction pathways that are both highly complex and commonly redundant. These signalling pathways can be both dependent and independent of receptors, act through auto‐, para‐ or intracrine mechanisms and can be modified by hormonal signals. Despite many shared features, follicular melanocytes appear to be more sensitive than epidermal melanocytes to ageing influences. This can be seen most dramatically in hair greying/canities and this is likely to reflect significant differences in the epidermal and follicular microenvironments. The hair follicle pigmentary unit may also serve as an important environmental sensor, whereby hair pigment contributes to the rapid excretion of heavy metals, chemicals and toxins from the body by their selective binding to melanin; rendering the hair fibre a useful barometer of exposures. The recent availability of advanced cell culture methodologies for isolated hair follicle melanocytes and for intact anagen hair follicle organ culture should provide the research tools necessary to elucidate the regulatory mechanisms of hair follicle pigmentation. In the longer term, it may be feasible to develop hair colour modifiers of a biological nature to accompany those based on chemicals.

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“…VPA has been reported to have several effects on hair growth, including alopecia, thinning of the hair, and hair‐color changes (Herranz et al, 1981; Bublin and Thompson, 1992). The prevalence of VPA‐induced hair‐texture changes was reported to be 11% in a study on 284 patients (Covanis et al, 1982).…”

Section: Discussionmentioning

confidence: 99%