Hair Repigmentation in a Hepatitis C Patient Treated with Interferon and Ribavirin

Kavak, Ayşe; Akcan, Yusuf; Korkmaz, Uğur

doi:10.1159/000086455

Cited by 13 publications

(7 citation statements)

References 6 publications

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“…Although hair greying is generally considered a progressive and irreversible age-related process, with the exclusion of alopecia areata ( McBride and Bergfeld, 1990 ), cases of drug- and mineral deficiency-induced depigmentation or repigmentation of hair have been reported ( Kavak et al, 2005 ; Kobayashi et al, 2014 ; Komagamine et al, 2013 ; Reynolds et al, 1989 ; Ricci et al, 2016 ; Sieve, 1941 ; Yoon et al, 2003 ) reflecting the influence of environmental inputs into HFPU function ( Paus et al, 2014 ). Because most hairs are continually growing from a living hair follicle, sensitive to changing physiological conditions, into a hardened hair shaft external to the body that retains stable molecular traces of these conditions, the hair shaft represents a bioarchive of recent exposures ( Kalliokoski et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative mapping of human hair greying and reversal in relation to life stress

Rosenberg

Rausser

Ren

et al. 2021

eLife

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Background:Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress.Methods:Here, we develop an approach to profile hair pigmentation patterns (HPPs) along individual human hair shafts, producing quantifiable physical timescales of rapid greying transitions.Results:Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. Combining HPP profiling and proteomics on single hairs, we also report hair greying and reversal that can occur in parallel with psychological stressors. To generalize these observations, we develop a computational simulation, which suggests a threshold-based mechanism for the temporary reversibility of greying.Conclusions:Overall, this new method to quantitatively map recent life history in HPPs provides an opportunity to longitudinally examine the influence of recent life exposures on human biology.Funding:This work was supported by the Wharton Fund and NIH grants GM119793, MH119336, and AG066828 (MP).

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Section: Introductionmentioning

confidence: 99%

Quantitative mapping of human hair greying and reversal in relation to life stress

Rosenberg

Rausser

Ren

et al. 2021

eLife

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“…Several drugs have been associated with hair repigmentation. These are verapamil, 3 cisplatin, 4 cyclosporin, 5 etretinate, 6 levodopa 7 and recently interferon–ribavirin association 8 . To the best of our knowledge, repigmentation of white hair after systemic corticosteroids, as the case of our patient, has not been reported previously.…”

mentioning

confidence: 62%

“…Corticosteroid‐induced hair darkening in our patient is very likely, because there is a compatible duration of 4 months after starting the treatment. In previously reports, pigmentation of hair occurs after 3 to 12 months of treatment 8 . Post‐inflammatory induction is unlikely because as previously mentioned, there is no scalp involvement by bullous pemphigoid.…”

mentioning

confidence: 75%

Repigmentation of the white hair after systemic corticosteroids for bullous pemphigoid

Khaled¹,

Trojjets²,

Zeglaoui³

et al. 2008

Acad Dermatol Venereol

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stopped ART long back. Investigations revealed CD4 + counts 12 cells/mL, reactive Toxoplasma-IgM ELISA, haemoglobulin 8 g% and ESR 95 mm in first hour. He could not afford viral load studies. With reinstitution of triple ART and prophylaxis for opportunistic infections, he was free of all skin/scrotal lesions within a week. DiscussionHIV-associated psoriasis usually develops in non-terminal stages of AIDS and is frequently severe, recalcitrant to therapy and has associated arthritis six times more often. 4 The clinical appearance is rather uniform with facial seborrhea, scalp, flexural and acral involvement, palmoplantar pustulosis and asymptomatic arthritis. 5 A considerable clinical overlap occurs between psoriasis, psoriatic arthropathy and Reiter's syndrome that correlates with the presence of HLA-B27, suggesting that HIV-associated psoriasis and Reiter's syndrome perhaps constitutes a continuum of similarly expressed cutaneous disease in genetically predisposed individuals manifesting with a psoriatic spectrum having Reiter's dsyndrome as its severest manifestation. 2,4 Although his past immune status was uncertain, he had similar manifestations at that time and a diagnostic/therapeutic dilemma of Reiter's syndrome for years.HIV infection shares many immunologic features with psoriasis including increased production of cytokines relevant to pathogenesis of psoriasis. 6,7 There is evidence that HIV plays a direct role in the pathogenesis of HIV-related psoriasis in genetically predisposed patients. 3,8,9 However, degree of immunosuppression and the type or severity of HIV-related psoriasis show no correlation. Paradoxically, it worsens with immunosuppression unlike classical psoriasis. Falling CD4 + cell counts (as observed in our patient) or ART resistance precipitates psoriasis relapses while clinical improvement occurs in the absence of viral replication implying that efficacy of ART in HIV-related psoriasis is attributable to improved cytokine imbalance/ immunosuppression following reduction of HIV load rather than to CD4 + cells. 3,10 Excellent response to triple ART in our patient substantiates foregoing observations. As the therapeutic effect seems only suppressive, ART irrespective of CD4 + cell counts would greatly improve survival and quality of life in these patients. VK Mahajan, NL References1 Buccheri L, Katchen BR, Karte AJ, Cohen SR. Acitretin therapy is effective for psoriasis associated with Human Immunodeficiency virus infection. Arch Dermatol 1997; 133: 711-715. 2 Breuer-McHam J, Marshall G, Adu-Oppong A et al. Alterations in HIV expression with psoriasis or pruritus treated with phototherapy. J Am Acad Dermatol 1999; 40: 48 -60. 3 Duvic M, Crane MM, Conant M, Mahoney SE, Reveille JD, Lehrman SN. Zidovudine improves psoriasis in human immunodeficiency virus-positive males. Arch Dermatol 1994; 130: 447-451. 4 Reveille JD, Conant MA, Duvic M. Human immunodeficiency virus-associated psoriasis, psoriatic arthritis and Reiter's syndrome: a disease continuum. Arthritis Rheum 1990; 33: 1574-157...

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“…There are single case reports of generalized hypertrichosis (43), hair curling (44) and hair repigmentation associated with interferon treatment (45).…”

Section: Other Hair Changesmentioning

confidence: 99%

A Review of Adverse Cutaneous Drug Reactions Resulting from the Use of Interferon and Ribavirin

Mistry

Shapero

Crawford

2009

Canadian Journal of Gastroenterology

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Drug-induced cutaneous eruptions are named among the most common side effects of many medications. Thus, cutaneous drug eruptions are a common cause of morbidity and mortality, especially in hospital settings. The present article reviews different presentations of drug-induced cutaneous eruptions, with a focus on eruptions reported secondary to the use of interferon and ribavirin. Presentations include injection site reactions, psoriasis, eczematous drug reactions, alopecia, sarcoidosis, lupus, fixed drug eruptions, pigmentary changes and lichenoid eruptions. Also reviewed are findings regarding life-threatening systemic drug reactions.

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Hair Repigmentation in a Hepatitis C Patient Treated with Interferon and Ribavirin

Cited by 13 publications

References 6 publications

Quantitative mapping of human hair greying and reversal in relation to life stress

Quantitative mapping of human hair greying and reversal in relation to life stress

Repigmentation of the white hair after systemic corticosteroids for bullous pemphigoid

A Review of Adverse Cutaneous Drug Reactions Resulting from the Use of Interferon and Ribavirin

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