Quantitative mapping of human hair greying and reversal in relation to life stress

Rosenberg, A; Rausser, Shannon; Ren, Junting; Mosharov, Eugene V.; Sturm, Gabriel; Ogden, R. Todd; Patel, Purvi; Soni, Rajesh Kumar; Lacefield, Clay; Tobin, Desmond J.; Paus, Ralf; Picard, Martin

doi:10.7554/elife.67437

Cited by 36 publications

(42 citation statements)

References 123 publications

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“…These preserved MeSCs with normal morphology and functionality can recolor newly regenerated hairs in next hair cycle. Consistently, a more recent study in humans showed that hair graying and hair recoloring can occur in parallel with stress exposures in young individuals of 9-39 years old (Rosenberg et al, 2021). Hair graying and recoloring can be observed within a single hair shaft in humans but not in mice.…”

Section: Neural Microenvironmentsupporting

confidence: 61%

Hair Graying Regulators Beyond Hair Follicle

Chen

Zheng

et al. 2022

Front. Physiol.

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Hair graying is an interesting physiological alteration associated with aging and certain diseases. The occurrence is due to depigmentation of the hair caused by depletion and dysfunction of melanocyte stem cells (MeSCs). However, what causes the depletion and dysfunction of MeSCs remains unclear. MeSCs reside in the hair follicle bulge which provides the appropriate niche for the homeostasis of various stem cells within hair follicle including MeSCs. In addition to local signaling from the cells composed of hair follicle, emerging evidences have shown that nerves, adipocytes and immune cells outside of hair follicle per se also play important roles in the regulation of MeSCs. Here, we review the recent studies on different cells in the MeSCs microenvironment beyond the hair follicle per se, discuss their function in regulating hair graying and potentially novel treatments of hair graying.

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Section: Neural Microenvironmentsupporting

confidence: 61%

Hair Graying Regulators Beyond Hair Follicle

Chen

Zheng

et al. 2022

Front. Physiol.

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“…Mitochondria play a vital role in skin and there exists increasing evidence that mitochondrial dysfunction and oxidative stress are key features in senescence and aging skin with direct links to skin and hair aging phenotypes (e.g., uneven pigmentation and hair graying). 68,212,213 Melatonin is found in especially high concentrations in mitochondria, 214,215 where it is transported to, 216 synthesized, 217 or metabolized. 92 Within mitochondria, cytochrome c converts melatonin to its potent antioxidant metabolite, AFMK, 91 and its secondary product, AMK in the presence of H 2 O 2 .…”

Section: Melatonin Regulates Senescence Progression and Promotes Mito...mentioning

confidence: 99%

Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective

Sevilla

Chéret

Slominski

et al. 2022

Journal of Pineal Research

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The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators by its versatility of functions and mechanisms of action, which include the regulation of vertebrate pigmentation. Although first discovered through its potent skin‐lightening effects in amphibians, melatonin's role in human skin and hair follicle pigmentation and its impact on melanocyte physiology remain unclear. Synthesizing our limited current understanding of this role, we specifically examine its impact on melanogenesis, oxidative biology, mitochondrial function, melanocyte senescence, and pigmentation‐related clock gene activity, with emphasis on human skin, yet without ignoring instructive pointers from nonhuman species. Given the strict dependence of melanocyte functions on the epithelial microenvironment, we underscore that melanocyte responses to melatonin are best interrogated in a physiological tissue context. Current evidence suggests that melatonin and some of its metabolites inhibit both, melanogenesis (via reducing tyrosinase activity) and melanocyte proliferation by stimulating melatonin membrane receptors (MT1, MT2). We discuss whether putative melanogenesis‐inhibitory effects of melatonin may occur via activation of Nrf2‐mediated PI3K/AKT signaling, estrogen receptor‐mediated and/or melanocortin‐1 receptor‐ and cAMP‐dependent signaling, and/or via melatonin‐regulated changes in peripheral clock genes that regulate human melanogenesis, namely Bmal1 and Per1. Melatonin and its metabolites also accumulate in melanocytes where they exert net cyto‐ and senescence‐protective as well as antioxidative effects by operating as free radical scavengers, stimulating the synthesis and activity of ROS scavenging enzymes and other antioxidants, promoting DNA repair, and enhancing mitochondrial function. We argue that it is clinically and biologically important to definitively clarify whether melanocyte cell culture‐based observations translate into melatonin‐induced pigmentary changes in a physiological tissue context, that is, in human epidermis and hair follicles ex vivo, and are confirmed by clinical trial results. After defining major open questions in this field, we close by suggesting how to begin answering them in clinically relevant, currently available preclinical in situ research models.

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“…Hair graying is usually a progressive process starting from middle age. Color of a single hair can sometimes swing between black and white (Rosenberg et al, 2021), suggesting that it is a reversible process at least in early stages. Aging-related hair graying largely attributes to loss of melanocytes and melanocyte stem cells (MeSCs) (Nishimura et al, 2005).…”

Section: Pigment Changes During Agingmentioning

confidence: 99%

“…This can be resulted from the aging of HFSCs that forms the niche environment of MeSCs . It was also found that stress-induced neuronal activity can cause hair graying by norepinephrine mediated MeSCs loss (Rosenberg et al, 2021;Zhang et al, 2020a). Notably, human hair graying is not only a color change but also associated with alterations in the biophysical properties and growth rate of the hair shaft (Van Neste and Tobin, 2004), implicating profound changes in the graying HF's epithelial lineage.…”

Section: Pigment Changes During Agingmentioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

155

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Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

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Quantitative mapping of human hair greying and reversal in relation to life stress

Cited by 36 publications

References 123 publications

Hair Graying Regulators Beyond Hair Follicle

Hair Graying Regulators Beyond Hair Follicle

Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective

The landscape of aging

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