Valproic Acid–induced Hair‐texture Changes in a White Woman

Wilting, Ingeborg; Laarhoven, J. H. M. van; Koning-Verest, Ingrid F. de; Egberts, Toine C. G.

doi:10.1111/j.1528-1167.2006.00933.x

Cited by 17 publications

(18 citation statements)

References 7 publications

(6 reference statements)

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“…[1] The clinical utility of this drug may be compromised by its adverse drug reaction (ADR) such as tremor, weight gain, hair loss, and gastrointestinal disturbances, heart burn, liver dysfunction, and thrombocytopenia. [2] Hair loss, being one of the ADR with valproate having incidence of 3.5%,[3] is diffused and non-scarring, which is related with high drug level.…”

Section: Introductionmentioning

confidence: 99%

Serum drug level-related sodium valproate-induced hair loss

Ramakrishnappa

Belhekar

2013

Indian J Pharmacol

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Sodium valproate is a well-established treatment in epilepsy and mood disorders. Its utility is compromised by its adverse effects such as tremor, weight gain, hair loss, and liver dysfunction. Hair loss may occur when drug is used in higher dose. Drug-induced hair loss is diffused and non-scarring, which is reversible upon withdrawal. But there are no case reports showing relation between serum levels of valproate and occurrence of hair loss. So we took interest in reporting this case report.

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Section: Introductionmentioning

confidence: 99%

Serum drug level-related sodium valproate-induced hair loss

Ramakrishnappa

Belhekar

2013

Indian J Pharmacol

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“…25 Possibly, the chelating properties of VPA can explain the effects on the hair structure. Several metals are essential for hair growth and keratinisation 26 Decreased copper, zinc and magnesium concentrations were found in subjects treated with VPA. 27 Of all the ADRs in our study 4.4% of the ADRs were related to urogenital system, which included nocturia and increased frequency of micturition were observed in patients on VPA therapy.…”

Section: Discussionmentioning

confidence: 99%

Study of adverse drug effects of antiepileptic drugs used in pediatric patients in a tertiary care rural hospital – a Pharmacovigilance study

Suman¹,

Gosavi²

2017

JYP

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Objective: To assess the prescription pattern & Adverse Drug Reaction (ADR)) profile of Antiepileptic drug (AEDs) therapy in children of rural population. Materials and Methods: This prospective open label, observational study was carried out over one and half year duration on 142 newly diagnosed epileptic children below 12 yrs age receiving AEDs in pediatric department in a tertiary care rural hospital. Follow up was done every month for 6 months duration. Prescription pattern and incidence, causality and severity of ADRs due to AEDs were assessed at each visit. Results: Out of 142 patients on AEDs, 97.2% patients were on mono-therapy and 2.8% patients were on poly-therapy. Valproic acid was the most commonly prescribed drug (58) and Lorazepam was the least prescribed drug (1). Central nervous system related ADRs (50%) were most common followed by gastrointestinal system (14.7%). Sedation and gastrointestinal distress were among the most frequently reported ADRs and29.4% of probable category while 70.5% ADR's were possible category. 72% ADRs were mild, 22% were moderate and 5.8% of ADRs were severe. Conclusions: Children receiving AEDs should be closely monitored for the development of any ADRs, especially related to their behavior and cognition. as it can influence their learning and memory, Active surveillance can help in knowing the exact incidence of ADRs. This study emphasizes on the role of patient / parent education and importance of health care professionals in pharmacovigilance studies.

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“…Genelde tedaviye dirençli olan bu saç dökülmesinde doz azalt›lmas› ya da ilac›n kesilmesi gerekebilmektedir 14 . Bu ilaçlar ayr›ca baz› hastalarda da saçlar›n dalgal› olmas›na ya da renk de¤iflikli¤ine neden olabilmektedir 16,15 .…”

Section: Bipolar Bozuklukunclassified

Deri Hastalıklarının Psikojenik Sonuçları ve Komorbiditeler

Mercan¹

2012

Turkderm

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Valproic Acid–induced Hair‐texture Changes in a White Woman

Abstract: We describe a 47-year-old white female patient experiencing several hair-texture changes during treatment with valproic acid (VPA). Curling of the hair was the most pro-

Cited by 17 publications

References 7 publications

Serum drug level-related sodium valproate-induced hair loss

Serum drug level-related sodium valproate-induced hair loss

Study of adverse drug effects of antiepileptic drugs used in pediatric patients in a tertiary care rural hospital – a Pharmacovigilance study

Deri Hastalıklarının Psikojenik Sonuçları ve Komorbiditeler

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