Drug Eruptions

Allergy and the Skin

“…Fixed drug eruptions, being one of the most straightforward and reliable of allergic reactions, might have been expected to furnish experimental evidence of the antigenic binding but the available evidence is confusing and conflicting. Wise & Sulzberger (1933) found by transplanting full thickness grafts from normal skin into the sensitized areas, and vice versa, that the grafted skin quickly acquired the behaviour of the surrounding skin. Naegeli (1930), however, obtained the opposite effect with Thiersch grafts, i.e.…”