Drug Eruptions

Sulzberger, Marion B.

doi:10.1001/archderm.1933.01460040002001

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Experiments With Picric a Cid1

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1935

1956

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Cited by 24 publications

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“…Thus Sulzberger and Wise (13) remark "that the application to a burned area (injured area) may constitute a situation peculiarly favoring sensitization." With this in view and on account of previous negative results with picric acid (1) upon intracutaneous injection in guinea pigs, butesin picrate was applied superficially to skin areas inflamed following application of cantharidin which produces lesions similar to burns.…”

Section: Experiments With Picric a Cidmentioning

confidence: 99%

Studies on the Sensitization of Animals With Simple Chemical Compounds

Landsteiner

Somma

1940

Journal of Experimental Medicine

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Sensitization of guinea pigs to picric acid was obtained by application of oil solutions to the skin, preferably on inflamed sites or by treatment with a compound of picric acid with n-butyl-p-aminobenzoate. The lesions obtained in sensitive animals on superficial administration bore resemblance to human eczema. It seems probable that picric acid sensitization is an instance where a substance does not sensitize directly but after conversion into a more reactive compound, a principle which should be of wider application to instances where the original substance does not readily form conjugates.

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Section: Experiments With Picric a Cidmentioning

confidence: 99%