Ion-exchange and filter-paper columns were used in a separation of amino acids from an extract of Astragalus bisulcatus. Two amino acids were identified, S-methylcysteine and Se-methylselenocysteine.
Sensitization of guinea pigs to picric acid was obtained by application of oil solutions to the skin, preferably on inflamed sites or by treatment with a compound of picric acid with n-butyl-p-aminobenzoate. The lesions obtained in sensitive animals on superficial administration bore resemblance to human eczema.
It seems probable that picric acid sensitization is an instance where a substance does not sensitize directly but after conversion into a more reactive compound, a principle which should be of wider application to instances where the original substance does not readily form conjugates.
With the view of making new types of chemicals accessible for investigations on drug hypersensitiveness, methods have been devised for sensitizing animals with diazomethane and mustard oil, two non-aromatic compounds.
Guinea pigs have been sensitized to diazomethane, a substance of high reactivity and known to cause severe allergic effects in man.
With the second substance, allylisothiocyanate, likewise capable of forming conjugates with substances in the animal body, sensitization effects have been obtained in man and in hogs. Sensitization in human beings was successful with one out of six individuals treated.
The observations indicate species and individual differences as regards the ability to become sensitized to various chemical compounds.
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