Drug-Encapsulated Cyclodextrin Nanosponges

Tannous, Maria; Caldera, Fabrizio; Hoti, Gjylije; Dianzani, Umberto; Cavalli, Roberta; Trotta, Francesco

doi:10.1007/978-1-0716-0920-0_19

Cited by 22 publications

(12 citation statements)

References 105 publications

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“…Both nanohydrogels showed negative surface charges suitable for avoiding the nanosponge aggregation phenomenon, thus indicating their ability to form physically stable nanosuspensions in an aqueous medium. After loading with RK, a slight increase (about 15%) of the particle size was observed together with the decrease of zeta potential values which could be attributable to the interaction between RK and NSs and the formation of the drug complex [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Tannous

Appleton

Hoti

et al. 2022

Gels

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Macrolides are widely used antibiotics with a broad spectrum of activity. The development of drug carriers to deliver this type of antibiotics has attracted much research. The present study aims at developing new swellable dextrin-based nanohydrogels for the topical delivery of rokitamycin, as model macrolide. Rokitamycin is a synthetic analogous of macrolides with advantageous characteristics as far as bacterial uptake and post-antibiotic effect are concerned. It is also indicated for the treatment of severe infections caused by Acanthamoeba and for topical infections. The nanohydrogels have been prepared from two types of cross-linked polymers obtained by using β-cyclodextrin or Linecaps® was provided by the Roquette Italia SPA (Cassano Spinola, Al, Italy) as building blocks. The cross-linked polymers have been then formulated into aqueous nanosuspensions refined and tuned to achieve the incorporation of the drug. Cross-linked β-cyclodextrin (β-CD) and Linecaps® (LC) polymers formed dextrin-based nanohydrogels with high swelling degree and mucoadhesion capability. Rokitamycin was loaded into the nanohydrogels displaying an average size around 200 nm with negative surface charge. In vitro kinetic profiles of free and loaded drug in nanohydrogels were compared at two pH levels. Interestingly, a sustained and controlled release was obtained at skin pH level due to the high degree of swelling and a pH responsiveness possibly. The results collected suggest that these nanohydrogels are promising for the delivery of rokitamycin and may pave the way for the topical delivery of other macrolide antibiotics.

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Section: Resultsmentioning

confidence: 99%

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Tannous

Appleton

Hoti

et al. 2022

Gels

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“…One of the most relevant applications is in drug delivery, highlighting in this field the use of CDNSs for cancer therapy ( Subramanian et al, 2012 ; Trotta et al, 2012 , 2014 ; Lakkakula and Krause, 2013 ; Swaminathan et al, 2016 ; Venuti et al, 2017 ; Lembo et al, 2018 ; Osmani et al, 2018 ; Allahyari et al, 2019 ; Kumar and Rao, 2019 ; Menezes et al, 2019 ). This topic has been the subject of numerous review articles and book chapters, some of which are quite recent ( Ciesielska et al, 2020 ; Jain et al, 2020 ; Tannous et al, 2020 , 2021 ; Andaç et al, 2021 ; Babadi et al, 2021 ).…”

Section: Applicationsmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges: Overview and Opportunities

et al. 2022

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Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.

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“…CD-based polymers, either the CD-polymers, nanosponges, or CDcombinations with other polymers, can play an increasing role in topical applications, particularly in the mucosal and transdermal administrations [54,[56][57][58]. The controlled release of acyclovir in ocular and subcutaneous administrations from a (hydroxy)propyl methylcellulose/cellulose acetate phthalate sandwiched acyclovir-βCD complex was successful [49], but the composition is still far from an everyday application.…”

Section: Topical Antiviral Drugsmentioning

confidence: 99%

Cyclodextrins in the antiviral therapy

Jicsinszky

Martina

Cravotto

2021

Journal of Drug Delivery Science and Technology

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The main antiviral drug-cyclodextrin interactions, changes in physicochemical and physiological properties of the most commonly used virucides are summarized. The potential complexation of antiviral molecules against the SARS-Cov2 also pointed out the lack of detailed information in designing effective and general medicines against viral infections. The principal problem of the current molecules is the 3D structures of the currently active compounds. Improving the solubility or bioavailability of antiviral molecules is possible, however, there is no universal solution, and the complexation experiments dominantly use the already approved cyclodextrin derivatives. This review discusses the basic properties of the different cyclodextrin derivatives, their potential in antiviral formulations, and the prevention and treatment of viral infections. The biologically active new cyclodextrin derivatives are also discussed.

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Drug-Encapsulated Cyclodextrin Nanosponges

Cited by 22 publications

References 105 publications

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery

Cyclodextrin-Based Nanosponges: Overview and Opportunities

Cyclodextrins in the antiviral therapy

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