Cyclodextrins in the antiviral therapy

Jicsinszky, László; Martina, Katia; Cravotto, Giancarlo

doi:10.1016/j.jddst.2021.102589

Cited by 29 publications

(37 citation statements)

References 218 publications

(243 reference statements)

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“…The CD is functionalized with sulfonic acid groups to mimic the negatively charged surface of cell receptors, commonly used by the viruses for attachment (i.e., heparan sulfate proteoglycans), thus preventing virus entry into cells [ 81 ]. Certainly, CDs’ versatility in the development of antiviral therapies makes them an appealing tool that is gaining attention in the fight against viral infections, including SARS-CoV-2 [ 70 , 82 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

et al. 2021

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We present a data-driven approach to unveil the pharmaceutical technologies of cyclodextrins (CDs) by analyzing a dataset of CD pharmaceutical patents. First, we implemented network science techniques to represent CD patents as a single structure and provide a framework for unsupervised detection of keywords in the patent dataset. Guided by those keywords, we further mined the dataset to examine the patenting trends according to CD-based dosage forms. CD patents formed complex networks, evidencing the supremacy of CDs for solubility enhancement and how this has triggered cutting-edge applications based on or beyond the solubility improvement. The networks exposed the significance of CDs to formulate aqueous solutions, tablets, and powders. Additionally, they highlighted the role of CDs in formulations of anti-inflammatory drugs, cancer therapies, and antiviral strategies. Text-mining showed that the trends in CDs for aqueous solutions, tablets, and powders are going upward. Gels seem to be promising, while patches and fibers are emerging. Cyclodextrins’ potential in suspensions and emulsions is yet to be recognized and can become an opportunity area. This is the first unsupervised/supervised data-mining approach aimed at depicting a landscape of CDs to identify trending and emerging technologies and uncover opportunity areas in CD pharmaceutical research.

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Section: Resultsmentioning

confidence: 99%

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

et al. 2021

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“…Considering these characteristics, some applications of CD-based polymers include, e.g., (i) increasing the solubility of poorly soluble drugs, (ii) modulating drug release and activity, (iii) the protection of drugs from degradation, (iv) enhancing bioactivities, (v) the adsorption of undesired substances, and (vi) gene delivery [ 10 , 11 , 12 , 13 , 14 ]. In the field of virology, CDs have been recently proposed as potential antiviral agents, both as drug delivery systems and molecules with intrinsic antiviral action [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Francese

Cecone

Costantino

et al. 2022

IJMS

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Cyclodextrins and cyclodextrin derivatives were demonstrated to improve the antiviral potency of numerous drugs, but also to be endowed with intrinsic antiviral action. They are suitable building blocks for the synthesis of functionalized polymer structures with potential antiviral activity. Accordingly, four water-soluble hyper-branched beta cyclodextrin (βCD)-based anionic polymers were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). They were characterized by FTIR-ATR, TGA, elemental analyses, zeta-potential measurements, and potentiometric titrations, while the antiviral activity was investigated with specific in vitro assays. The polymer with the highest negative charge, pyromellitic dianhydride-linked polymer (P_PMDA), showed significant antiviral action against RSV and HSV-2, by inactivating RSV free particles and by altering HSV-2 binding to the cell. The polymer fraction with the highest molecular weight showed the strongest antiviral activity and both P_PMDA and its active fractions were not toxic for cells. Our results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact. Additionally, the strong HSV-2 binding inhibition along with the water solubility of P_PMDA and the acyclovir complexation potential of βCD are attractive features for developing new therapeutic topical options against genital HSV-2 infection.

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“…Interestingly, CDs play a role in fighting the COVID-19 pandemic. For example, CDs can be found in formulations of remdesivir [10] (an antiviral drug administered to treat COVID-19) and Johnson & Johnson's Jannsen (J&J/Janssen) single-shot COVID-19 vaccine [11]. CDs are also utilized in the production of face masks, which are widely used to help slow the spread of the coronavirus [12].…”

Section: Introductionmentioning

confidence: 99%

Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes

Mazurek

Szeleszczuk

Gubica

2021

IJMS

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Cyclodextrins (CDs) are highly respected for their ability to form inclusion complexes via host–guest noncovalent interactions and, thus, ensofance other molecular properties. Various molecular modeling methods have found their applications in the analysis of those complexes. However, as showed in this review, molecular dynamics (MD) simulations could provide the information unobtainable by any other means. It is therefore not surprising that published works on MD simulations used in this field have rapidly increased since the early 2010s. This review provides an overview of the successful applications of MD simulations in the studies on CD complexes. Information that is crucial for MD simulations, such as application of force fields, the length of the simulation, or solvent treatment method, are thoroughly discussed. Therefore, this work can serve as a guide to properly set up such calculations and analyze their results.

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Cyclodextrins in the antiviral therapy

Cited by 29 publications

References 218 publications

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes

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