Drug Delivery Systems from Self-Assembly of Dendron-Polymer Conjugates †

Bolu, Burcu Sumer; Sanyal, Rana; Sanyal, Amitav

doi:10.3390/molecules23071570

Cited by 55 publications

(41 citation statements)

References 122 publications

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“…16 In a previous work we had explored different amphiphilic cationic dendritic derivatives based on 2,2′-bis(hydroxymethyl)propionic acid (bis-MPA) 17 as nanocarriers for the targeted delivery of antimalarial drugs. 18 These dendritic derivatives consisted of Janus dendrimers 19 or hybrid dendriticlinear-dendritic block copolymers (HDLDBC), 20 and both selfassembled into micelles with glycine groups at the surface. Although some of these structures exhibited specific pRBC targeting and in vitro antimalarial activity, they had an excessive unspecific toxicity, a very large size after antimalarial drug loading (>150 nm), and their in vivo tests had been preliminary.…”

Section: Introductionmentioning

confidence: 99%

Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

et al. 2019

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“…For example, exposure to biological fluids (i.e., ionic electrolytes) may disrupt interior guest-host interactions leading to A wide range of linear-dendritic architectural copolymer structures have been reported to undergo supramolecular assemble to form a diversity of soluble dendritic nanostructures suitable for drug delivery (Figure 39). This very active area has recently been reviewed recently by Bolu and the Sanyal et al [113].…”

Section: Supramolecular Guest Encapsulation/aggregation or Covalent Cmentioning

confidence: 99%

“…A wide range of linear-dendritic architectural copolymer structures have been reported to undergo supramolecular assemble to form a diversity of soluble dendritic nanostructures suitable for drug delivery (Figure 39). This very active area has recently been reviewed recently by Bolu and the Sanyal et al [113]. Although non-covalent drug complexation/entrapment in dendrimers is the preferred technique for solubilizing many drugs, this approach has some limitations.…”

Section: Supramolecular Guest Encapsulation/aggregation or Covalent Cmentioning

confidence: 99%

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The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

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“…Polymer-drug conjugates or prodrugs are macromolecular dispersed systems that require covalent binding of the active principle while nanoparticles on the contrary are physically attached to the active principle. Polymer-drug conjugates have low molecular weight (specific to polymer incorporation), which permits molecular targeting within the cancer cell [42,43]. Physicochemical properties of polymer-drug conjugates (pH, enzymatic-alteration, acid (H + )-catalytic chemical reactions) are vital for drug release at a tumour site.…”

Section: Critical Comparison Of Nanosystems To Nanomicelles For Oc Trmentioning

confidence: 99%

Nanodrug Delivery Systems for the Treatment of Ovarian Cancer

Pantshwa

Kondiah

Choonara

et al. 2020

Cancers

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Despite advances achieved in medicine, chemotherapeutics still has detrimental side effects with ovarian cancer (OC), accounting for numerous deaths among females. The provision of safe, early detection and active treatment of OC remains a challenge, in spite of improvements in new antineoplastic discovery. Nanosystems have shown remarkable progress with impact in diagnosis and chemotherapy of various cancers, due to their ideal size; improved drug encapsulation within its interior core; potential to minimize drug degradation; improve in vivo drug release kinetics; and prolong blood circulation times. However, nanodrug delivery systems have few limitations regarding its accuracy of tumour targeting and the ability to provide sustained drug release. Hence, a cogent and strategic approach has focused on nanosystem functionalization with antibody-based ligands to selectively enhance cellular uptake of antineoplastics. Antibody functionalized nanosystems are (advanced) synthetic candidates, with a broad range of efficiency in specific tumour targeting, whilst leaving normal cells unaffected. This article comprehensively reviews the present status of nanosystems, with particular emphasis on nanomicelles for molecular diagnosis and treatment of OC. In addition, biomarkers of nanosystems provide important prospects as chemotherapeutic strategies to upsurge the survival rate of patients with OC.

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Drug Delivery Systems from Self-Assembly of Dendron-Polymer Conjugates †

Cited by 55 publications

References 122 publications

Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Nanodrug Delivery Systems for the Treatment of Ovarian Cancer

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