Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

Abstract

Biocompatible dendrimer-based carriers suitable for antimalarial drug transport: cell targeting and in vitro and in vivo analysis of Plasmodium growth inhibition.

Promising nanomaterials in the fight against malaria

“…dendronized hyperbranched molecules (DHP) (Fig. 9b), 128 and self-assembled amphiphilic structures, i.e. hybrid dendritic-linear-dendritic block copolymers (HDLDBC) ( Fig.…”

“…It displayed high drug loading capacity and good targeting towards pRBCs while showing a similar drug activity after encapsulation. 128 Artemisinin has been also covalently linked to 1st generation dendrimers leading to trimeric and tetrameric molecules. The trimeric dendrimer showed a higher drug activity in vitro than the free artesumic acid precursor and slightly lower than free dihydroartemisinin, whereas the tetrameric dendrimer exhibited a lower drug activity.…”

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

“…In this context, more and more complex oligomeric and polymeric units are being prepared to enhance the biocompatibility and loading properties as well as the circulation time by avoiding filtration in the kidneys and recognition by immune system and clearance. For example, recently Coma-Cros [150] reported micellar carriers based on hybrid dendritic-linear-dendritic block copolymers based on Pluronic ® F127 and dendrons made of amino-terminated 2,2 -bis(glycyloxymethyl)propionic acid, with a poly(ester amide) skeleton (HDLDBC-bGMPA) connected to an amino-terminated dendronized hyperbranched polymer with a polyester skeleton derived from 2,2 -bis(hydroxymethyl)propionic acid (DHP-bMPA). Chloroquine, primaquine, and quinacrine were loaded into those biocompatible nanosystems that presented drug loading capacity from 30% to 60% and were tested as antimalarials.…”

Acoustic radiation force optical coherence elastography for evaluating mechanical properties of soft condensed matters and its biological applications

“…Soft condensed matter has high similarity with characteristics of biological tissues; therefore, these have been exploited to investigate tissue mechanics and have been successful in explaining dynamical tissue behaviors such as surface tension, elasticity and viscosity [1]. Micelles have been identified to have representative complexity of soft matter systems [2] and have attracted much attention in areas such as nanocarriers for drug delivery [3][4][5][6][7][8][9], mechanical responses [10][11][12][13][14], and cancer treatment [15,16] due to the versatility of the rheological properties with small amphiphilic molecules and their spontaneous selfassembly in a simplicity of the design with surfactant, salt and water [10,[17][18][19].…”