Drug-Carrier Potential of Liposomes in Cancer Chemotherapy

Gregoriadis, Gregory; Swain, C.P.; Wills, E. J.; Tavill, Anthony S.

doi:10.1016/s0140-6736(74)90682-5

Cited by 287 publications

(89 citation statements)

References 9 publications

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“…This advance was made possible by the development of various types of micro-and nanosystems resulting from researches based on multidisciplinary approaches. Starting from the first liposomes proposed in 1974 by Gregoriadis (Gregoriadis et al 1974) there was an explosion in the number of microsystems suitable for drug delivery, which are either made of lipids or composed of polymers (Couvreur and Vauthier 2006). This paper describes new polymeric particles: alginate and chitosan based particles.…”

Section: Discussionmentioning

confidence: 99%

Alginate and chitosan particles as drug delivery system for cell therapy

Ciofani

Raffa

Menciassi

et al. 2007

Biomed Microdevices

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Drug-carrying microstructures which have a size similar to biological structures are very attractive to encapsulate drugs and protect them during the transit in the human body. This paper describes polymeric (alginate and chitosan) particles (average radius 500 nm) produced by homogenization techniques. In vitro studies performed on cell lines demonstrate the effectiveness of such particles for intracellular drug delivery. Our experiments suggest that cellular up - take increases linearly with particle concentration in the growth medium, and the internalization process has a first order kinetics (characteristic time around 0.5 h(-1)). In addition, the particles degrade within 24 h from the up-take without side effects for cell viability.

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Section: Discussionmentioning

confidence: 99%

Alginate and chitosan particles as drug delivery system for cell therapy

Ciofani

Raffa

Menciassi

et al. 2007

Biomed Microdevices

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“…Dendrimers are macromolecules displaying structural perfection; these are regularly hyperbranched, 3-dimensional, relatively low molecular weight, polydispersity and adjustable functionality (Sosnik et al, 2010 Liposomes are composite structures of nano to micro sizes consisting of a phospholipid bilayer that surrounds an aqueous core (Gregoriadis et al, 1974). Liposome's core can encapsulate water soluble drugs while the hydrophobic domain can entrap the insoluble agents (Sosnik et al, 2010), Fig.…”

Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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The kind of interactions which nanoparticles show in the biological systems is very interesting. Nanoparticles (NPs) on entering the living system immediately come in contact with proteins which serve many applications of nanoparticles including bio-signalling, therapeutics and drug delivery systems. Moreover, many inorganic oxide nanoparticles can also serve the purpose of antibacterial/antiviral by assisting in the production of reactive oxygen species (ROS). The role of nanoparticles in therapeutics is very significant and increasing day-by-day as it assures better treatment to the patient by enhancing activity of drug, improving bioavailability, flexibility in deciding route of administration and long term stability of drug resulting in better treatments of diseases. NPs such as solid lipid NPs, polymeric NPs, porous NPs, liposomes are being used for treatment of various types of diseases. Numerous carriers based drug delivery systems incorporating anti-TB drugs have been developed for target site actions. NPs encapsulating anti-cancer drugs such as doxorubicin, paclitaxel have also been developed for treatment of different types of cancers. Results of these studies give hopes to the researchers for the use of nanoparticles in the field of therapeutics. The NPs can be toxic as well as nontoxic to the biological system. Therefore, some adverse effects, such as, cytotoxicity on inhaling some kinds of nanoparticles must be kept in mind for judicious use of such systems during synthesis or during handling. The paper describes recent developments in the field by reviewing the available literature.

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“…Thus liposomes have been successfully applied as carriers of enzymes, in enzyme replacement therapy (8)(9), of anti-tumour drugs in cancer chemotherapy (10), and have also been used as immunological adjuvants (11) and for entrapment of synthetic polynucleotides such as polyuridylic acid (12) and synthetic double-stranded ribonucleic acid, poly(I):poly(C) for induction of interferon synthesis (13).…”

Section: Introductionmentioning

confidence: 99%

Entrapment of plasmid DNA in liposomes

Dimitriadis¹

1979

Nucl Acids Res

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The entrapment of plasmid DNA (pMB9) and high molecular weight DNA into large unilamellar liposomes is described. The entrapment of DNA is specific and due to encapsulation of DNA into the aqueous compartment of liposomes. The entrapped DNA, resistant to deoxyribonuclease treatment, could be reisolated from liposomes intact and, as has been shown by transformation assay, it remains biologically active. The advantages of our method and possible applications are discussed.

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Drug-Carrier Potential of Liposomes in Cancer Chemotherapy

Cited by 287 publications

References 9 publications

Alginate and chitosan particles as drug delivery system for cell therapy

Alginate and chitosan particles as drug delivery system for cell therapy

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Entrapment of plasmid DNA in liposomes

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