Drug addiction: a curable mental disorder?

Liu, Jian-Feng; Li, Jun-xu

doi:10.1038/s41401-018-0180-x

Cited by 45 publications

(20 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, RFTN1 contributes to multiple immune-related biological pathways, including B and T cell receptor (BCR and TCR, respectively) signaling, toll-like receptor (TLR) 3 signaling, and interleukin-17 (IL17) production ( 37 – 40 ). It has been increasingly recognized that activation of central immune signaling by substances (e.g., opioids) can enhance drug reward ( 41 , 42 ). In mice, TLR3 modulates cocaine reward through pro-inflammatory immune signaling ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study of Smoking Behavior Traits in a Chinese Han Population

Chen

Yao

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

Tobacco use is one of the leading causes of preventable disease worldwide. Genetic studies have elucidated numerous smoking-associated risk loci in American and European populations. However, genetic determinants for cigarette smoking in Chinese populations are under investigated. In this study, a whole-genome sequencing (WGS)based genome-wide association study (GWAS) was performed in a Chinese Han population comprising 620 smokers and 564 nonsmokers. Thirteen single-nucleotide polymorphisms (SNPs) of the raftlin lipid linker 1 (RFTN1) gene achieved genome-wide significance levels (P < 5 x 10 −8) for smoking initiation. The rs139753473 from RFTN1 and six other suggestively significant loci from CUB and sushi multiple domains 1 (CSMD1) gene were also associated with cigarettes per day (CPD) in an independent Chinese sample consisting of 1,329 subjects (805 smokers and 524 nonsmokers). When treating males separately, associations between smoking initiation and PCAT5/ANKRD30A, two genes involved in cancer development, were identified and replicated. Within RFTN1, two haplotypes (i.

show abstract

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study of Smoking Behavior Traits in a Chinese Han Population

Chen

Yao

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Tanto a harmina e a harmalina são inibidores de enzimas como a acetilcolinesterase (AChE), a mieloperoxidase (MPO) e a MAO (Li et al, 2018). A esta última cabe a responsabilidade de metabolizar a 5-HT (Pithadia & Jain, 2009).…”

Section: β-Carbolinas: Harmina E Harmalinaunclassified

“…Adicção às drogas é o termo usado para o estágio crônico mais grave do distúrbio do uso de substâncias, no qual há um substancial perda de autocontrole e um consumo compulsivo, apesar do desejo de parar e a despeito dos graves problemas de saúde adquiridos com o hábito (Liu & LI, 2018;Volkow et al 2016;Zou et al, 2017). De acordo com a Organização das Nações Unidas (ONU), a adicção às drogas é um problema mundial de saúde pública.…”

Section: Introductionunclassified

Mimosa tenuiflora (Willd.) Poir e Anadenanthera colubrina como alternativas no tratamento da adicção às drogas

Sousa

Leite

et al. 2021

RSD

View full text Add to dashboard Cite

A adicção às drogas é considerada um problema de saúde pública a nível mundial. Há poucas opções farmacoterapêuticas eficazes para o tratamento desta condição. Contudo, o uso de moléculas alucinógenas serotoninérgicas provenientes de plantas utilizadas em contextos religiosos como as encontradas na casca da raiz da Mimosa tenuiflora e nas sementes da Anadenanthera colubrina possuem grande potencial terapêutico ao reduzir comportamentos adictivos associados à abstinência. Este artigo apresenta as características etnofarmacológicas, fitoquímicas, farmacológicas e toxicológicas que podem embasar o estudo das plantas Mimosa tenuiflora e Anadenanthera colubrina no tratamento da adicção às drogas. No decorrer desta revisão narrativa, foram avaliados 159 textos onde foi possível observar que existem justificativas que podem endossar a investigação terapêutica destas plantas, principalmente ao se verificar a presença de moléculas alucinógenas serotoninérgicas como a N, N-dimetiltriptamina e a 5-OH-N, N-dimetiltriptamina, abrindo, portanto, a possibilidade do desenvolvimento e produção de novas opções terapêuticas anti-adictivas.

show abstract

“…Typical treatments for substance use disorders (SUDs) are drug‐type medications (methadone and buprenorphine) and behavioral treatments (such as cognitive therapy and community reinforcement), which have symptomatic benefit during detoxification and abstinence [1,2]. However, these treatments are only moderately effective.…”

Section: Introductionmentioning

confidence: 99%

Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta‐analysis of 74 studies

et al. 2020

View full text Add to dashboard Cite

Aims To characterize the peripheral inflammatory cytokine profile in people with substance use disorders (SUDs). Design Systematic review and meta‐analysis. Setting Clinical studies that evaluated peripheral blood inflammatory cytokine levels in patients with SUDs and healthy controls Participants SUD patients and healthy controls. Measurements PubMed and Web of Science were systematically searched for relevant studies. Two investigators independently selected studies and extracted data. A total of 77 articles were included in the meta‐analysis, containing 5649 patients with SUDs and 4643 healthy controls. Data were pooled using a random‐effects model by the Comprehensive Meta‐Analysis version 2 software. Findings Concentrations of interleukin (IL)‐6) in 32 studies, tumor necrosis factor (TNF)‐α in 28 studies, IL‐10 in 20 studies, IL‐8 in 17 studies, C‐reactive protein in 14 studies, IL‐4 in 10 studies, IL‐12 in seven studies, monocyte chemoattractant protein (MCP)‐1 in 6 studies, TNF‐receptor 2 (TNF‐R2) in four studies and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) in three studies were significantly higher in patients with SUDs compared with healthy controls, while concentrations of leptin in 14 studies were significantly lower in patients with SUDs compared with healthy controls. The findings were inconclusive for the associations between interferon‐γ, IL‐1β, IL‐2, IL‐1 receptor antagonist (IL‐1RA), transforming growth factor (TGF)‐β1, G‐CSF, C‐C motif chemokine 11, TGF‐α and SUDs. Conclusions People with substance use disorders (SUDs) appear to have higher peripheral concentrations of IL‐4, IL‐6, IL‐8, IL‐10, IL‐12, TNF‐α, C‐reactive protein, MCP‐1, TNF‐R2 and GM‐CSF and lower peripheral concentrations of leptin than people without SUDs. This strengthens the view that SUD is accompanied by an inflammatory response.

show abstract

Drug addiction: a curable mental disorder?

Cited by 45 publications

References 112 publications

Genome-Wide Association Study of Smoking Behavior Traits in a Chinese Han Population

Genome-Wide Association Study of Smoking Behavior Traits in a Chinese Han Population

Mimosa tenuiflora (Willd.) Poir e Anadenanthera colubrina como alternativas no tratamento da adicção às drogas

Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta‐analysis of 74 studies

Contact Info

Product

Resources

About