Drowning-out crystallization of l-proline: Effect of anti-solvent composition and processing parameters on crystal size and shape

Hyung, Woochan; Kim, Ye-Hoon; Chung, Chan‐Hwa; Haam, Seungjoo

doi:10.1016/j.powtec.2007.11.007

Cited by 13 publications

(8 citation statements)

References 5 publications

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“…When compared to evaporation methods, drowning-out crystallization is easy to perform, highly obtainable, and allows crystal separation at ambient temperature. These advantages have resulted in the widespread use of drowning-out crystallization in research areas varying from pharmaceutical chemistry to the synthesis of organic nanoparticles/nanostructures. , Solvent-induced crystallization, including the LLIP method and reprecipitation method, is similar to the drowning-out crystallization. In this study, C 60 crystals of various shapes were prepared by drowning-out crystallization using different alcohols, such as ethanol, 1-propanol, and 1-butanol, as the antisolvents.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents

et al. 2010

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Solvent-based synthetic methods of fullerene nano/microstructures are known to enhance and utilize unique optical and electrical properties of fullerene structures. Here, we report the systematic synthesis and characterization of various-shaped fullerene microcrystals using alcohols as antisolvents in drowning-out crystallization. The microcrystals are formed in one-, two-, and three-dimensional structures depending on the alcohol type, and the size and shape of the microcrystals are also varied by the C 60 concentration and the volume ratio of the solvents. X-ray diffraction patterns demonstrate that the crystalline structures differ from the chain lengths of alcohols. It is suggested that the formation mechanisms are driven by supersaturation related to the C 60 solubility in alcohols. This crystallization could allow for production of C 60 microcrystals with the desired shape and crystalline structure, leading to potential applications in optoelectronics and photoconducting devices.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents

et al. 2010

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“…Preliminary satisfactory results in terms of matrix processability were obtained with an HEC and P concentration of 0.2% and 5.0% w/v (Batch-3), respectively. Normally, the morphology of P shows a needle crystalline form [25] (Figure 1a) and the unprocessed extract appeared as a material in a cluster form with irregular shape and surface ( Figure 1b) and exploiting red and yellow fluorescence due to the different nature of polyphenols present in the extract (Figure 1b).…”

Section: Microencapsulation Process Morphological and Dimensional Cmentioning

confidence: 99%

“…Amino acids (arginine, phenylalanine, and leucine) are often used in the microencapsulation process as effective dispersibility enhancers able to load active ingredients [22][23][24]. Among amino acids, l-proline (P) possesses the highest solubility in water and alcohol, and it has been proven to be essential to produce collagen and healthy joints, tendons, and skin [25]. Some research reported the multifunctionality of P showing a protective role against cellular osmotic and oxidative stress, protein chaperoning, cell signaling, programmed cell death, and extracellular matrix (ECM) integrity.…”

Section: Introductionmentioning

confidence: 99%

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

et al. 2020

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An extract obtained from hazelnut shells by-products (HSE) has antioxidant and chemopreventive effects on human melanoma and cervical cancer cell lines, inducing apoptosis by caspase-3 activation. A clinical translation is limited by poor water solubility and low bioavailability. Dried plant extracts often show critical characteristics such as sticky/gummy appearance, unpleasant smell, and instability involving practical difficulties in processing for industrial use. A spray drying method has been applied to transform raw HSE in a microparticulate powder. The biopolymeric matrix was based on l-proline as loading carrier, hydroxyethylcellulose in combination with pectin as coating polymers; lecithin and ethanol were used as solubility enhancers. A Hot-Cold-Hot method was selected to prepare the liquid feed. The thus prepared powder showed good technological properties (solid-state, particle dimensions, morphology, and water dissolution rate), stability, and unchanged chemopreventive effects with respect to the unprocessed HSE.

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“…In this regard, many methods of agglomeration and polycrystalline growth of amino acid crystals have been extensively studied. Hyung et al attempted an antisolvent crystallization with sonication to produce l -proline agglomerates, but the procedure exhibited limited capability to be implemented in large scale . Toldy et al produced spherical agglomerates of glycine crystals in a water/dodecane emulsion using a microfluidic system .…”

Section: Introductionmentioning

confidence: 99%

“…Hyung et al attempted an antisolvent crystallization with sonication to produce L-proline agglomerates, but the procedure exhibited limited capability to be implemented in large scale. 5 Toldy et al produced spherical agglomerates of glycine crystals in a water/dodecane emulsion using a microfluidic system. 6 However, the technique suffers from a low production rate and difficulty in increasing the particle size.…”

Section: Introductionmentioning

confidence: 99%

Enhancement in Bulk Density of l-Methionine Agglomerates by Cooling Crystallization with pH Control Using Additives

Kim

Koo

2019

Crystal Growth & Design

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A cooling crystallization process with pH control was proposed to produce L-methionine (L-Met) agglomerates with improved bulk densities. L-Met was crystallized upon increasing the pH of an acidic L-Met solution by the injection of an electrolyte aqueous solution. Considering factors including the salting-out effect of the cation and hydrogen ion acceptability of the anion, sodium acetate was selected as an electrolyte. When acetate ions were added to the acidic L-Met solution, supersaturation was generated by the pH increase owing to the protonation of acetate ions. It was found that, as the decreasing rate of hydrogen ion concentration was faster, the metastable zone width, represented as a function of hydrogen ion concentration, increased and denser agglomerates were formed. Furthermore, when the suspension was cooled subsequently, L-Met agglomerates with the bulk density of 760 g/L were obtained, which was about 4-fold higher than that of hollow-structured agglomerates produced from a neutral L-Met solution by only the slow cooling process.

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Drowning-out crystallization of l-proline: Effect of anti-solvent composition and processing parameters on crystal size and shape

Cited by 13 publications

References 5 publications

Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents

Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

Enhancement in Bulk Density of l-Methionine Agglomerates by Cooling Crystallization with pH Control Using Additives

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Drowning-out crystallization of l-proline: Effect of anti-solvent composition and processing parameters on crystal size and shape

Cited by 13 publications

References 5 publications

Synthesis and Characterization of Various-Shaped C60 Microcrystals Using Alcohols As Antisolvents

Synthesis and Characterization of Various-Shaped C60 Microcrystals Using Alcohols As Antisolvents

Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells

Enhancement in Bulk Density of l-Methionine Agglomerates by Cooling Crystallization with pH Control Using Additives

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Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents

Synthesis and Characterization of Various-Shaped C₆₀ Microcrystals Using Alcohols As Antisolvents