Solvent-based synthetic methods of fullerene nano/microstructures are known to enhance and utilize unique optical and electrical properties of fullerene structures. Here, we report the systematic synthesis and characterization of various-shaped fullerene microcrystals using alcohols as antisolvents in drowning-out crystallization. The microcrystals are formed in one-, two-, and three-dimensional structures depending on the alcohol type, and the size and shape of the microcrystals are also varied by the C 60 concentration and the volume ratio of the solvents. X-ray diffraction patterns demonstrate that the crystalline structures differ from the chain lengths of alcohols. It is suggested that the formation mechanisms are driven by supersaturation related to the C 60 solubility in alcohols. This crystallization could allow for production of C 60 microcrystals with the desired shape and crystalline structure, leading to potential applications in optoelectronics and photoconducting devices.
Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.
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