The effects of one-step reaction orders have been studied on the ignitability of a fuel droplet in a fuellean, oxidant-lean, and both fuel-and oxidant-lean environments with nite ame location. The matched asymptotic analysis of large activation energy is employed with the Arrhenius kinetics and arbitrary fuel and oxidizer reaction orders. The variable thermophysical properties are taken to depend on both temperature and composition of the gas mixture with distinct binary diffusion coef cients and nonunity Lewis numbers. It is found that the ignition Damkö hler number varies signi cantly with the fuel and oxidant reaction orders, and decreases as the ambient fuel and oxidant concentration are increased. Autoignition is prevented if the ambient oxidant concentration is suf ciently low. It is also found that the mixture Lewis number should be de ned appropriately, depending on the ambient fuel and oxidant concentration if equal binary diffusion coef cients are used. The variable thermophysical properties affect ignition phenomenon partly through the droplet mass evaporation rate and partly through the thermal driving force for evaporation. By using an appropriate mixture Lewis number, the frozen evaporation rate and the thermal driving force, ignition event can be predicted accurately from the analysis with constant properties with equal binary diffusion coef cients.