Dringliche Keratoplastiken bei entzündlichen Hornhautprozessen

The results of keratoplasty à chaud in 49 eyes are reported. None of the eyes had to be enucleated. In 43% the transplant remained clear. The prognosis was best in cases of bacterial or fungal ulcers, provided that vascularization did not involve more than one quadrant. The results are compared with those of other authors who recommend the use of tissue adhesives first and only perform corneal grafting some months later.

Section: Introductionunclassified

Ergebnisse der Keratoplastik à chaud

Behrens–Baumann¹

1984

“…Da die Keratoplastik auch zur Behandlung entzündlicher Hornhautprozesse aufgrund verbesserter Operationstechnik mit groflem Erfolg eingesetzt wird (Ha!lermann 1967und 1975, Doden 1973, Weid! 1984, ist die mikrobiologische Untersuchung nicht nur zur Dekontamination des Spendermaterials, sondern auch für eine gezielte Chemotherapie des Empfangers eine unentbehrliche Voraussetzung, urn bei Vorhandensein pathogener Erreger die chirurgische Behandlung wirkungsvoll ergänzen zu können.…”

Section: Mit Zunehmender Aufenthaltsdauer Derunclassified

Beitrag zum Umfang bakterieller Kontaminationen bei Keratoplastik-Spenderaugen post mortem

Ritter

Gøtze²,

Trute³

et al. 1990

In order to determine the initial bacterial contamination of corneal donor material the abraded epithelia from 125 donors, i.e., 250 globes, were examined immediately after enucleation. Of these, 49 (19.6%) were sterile, while 201 (80.4%) were contaminated. Monoinfection was identified in 174 globes and mixed infection in 27. The pathogen most frequently isolated was Pseudomonas aeruginosa. Neither the donor's age not the time elapsed between death and enucleation had any influence on the contamination rate. Prolonged hospitalization of donors leads to an increase in gram-negative bacteria. The necessity of antibacterial prophylaxis prior to keratoplasty is pointed out.

“…vielen Fallen eine frUhzeitige Keratoplastik notwendig (De Voe, 1971). Wenngleich die Ergebnisse einer ,,Keratoplastik a chaud" gut sind (Doden, 1973;Böke und Thiel, 1974;Hallermann, 1975;Thiel, 1978;Behrens-Baumann, 1984), ist primar eine erfoigreiche konservative Therapie wUnschenswert.…”

unclassified

Experimentelle Untersuchungen zur lokalen Therapie der Candida-Keratomykose mit Amphotericin B

Behrens–Baumann¹,

Uter²,

Ansorg³

1987

The efficiency of Amphotericin B drops was studied using a newly developed keratomycosis model (defined strain Candida albicans DSM 70010, which leads reproducibly to a corneal infection with descemetocele without prior local or systemic immunosuppression in the rabbit). Penetration of the drug (administered ten times a day) into the cornea and aqueous humor was only demonstrated after abrasion of the corneal epithelium. Three groups were studied: (I) therapy with abrasion, (II) therapy without abrasion, and (III) a control group. Both clinically (descemetocele or perforation, hypopyon) and with regard to microbiology (reculture of Candida) the results obtained in Group I were significantly better than those obtained in Group II (p less than 0.001). Repeated corneal abrasion is therefore recommended for treatment of Candida keratitis with Amphotericin B.