Draft Genome Sequence of an IMP-7-Producing Pseudomonas aeruginosa Bloodstream Infection Isolate from Australia

McCarthy, Kate; Jennison, Amy V.; Wailan, Alexander M.; Paterson, David L.

doi:10.1128/genomea.00596-17

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Several years later, the same enzyme appeared in Italy in A. baumannii, representing its first description from European countries [80]. Additionally, IMP-2 from Italy and IMP-5 from Portugal were soon described [81] as well as IMP-4 from USA [82], both IMP-1 and 2 from the Middle East [83], and IMP-7 from Australia [84], which indicates that IMP genes were not solely restricted to the Far East region. Currently, the number of IMP varieties have reached about 50.…”

Section: Ambler Class B Carbapenemases (Metallo-β-lactamases)mentioning

confidence: 94%

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

2020

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Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent the most potent β-lactamases, which hydrolyze a broad variety of β-lactams, including carbapenems, cephalosporins, penicillin, and aztreonam. The major issues associated with carbapenemase production are clinical due to compromising the activity of the last resort antibiotics used for treating serious infections, and epidemiological due to their dissemination into various bacteria across almost all geographic regions. Carbapenemase-producing Enterobacteriaceae have received more attention upon their first report in the early 1990s. Currently, there is increased awareness of the impact of nonfermenting bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, as well as other Gram-negative bacteria that are carbapenemase-producers. Outside the scope of clinical importance, carbapenemases are also detected in bacteria from environmental and zoonotic niches, which raises greater concerns over their prevalence, and the need for public health measures to control consequences of their propagation. The aims of the current review are to define and categorize the different families of carbapenemases, and to overview the main lines of their spread across different bacterial groups.

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Section: Ambler Class B Carbapenemases (Metallo-β-lactamases)mentioning

confidence: 94%

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

2020

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“…Notably, IMP-6 has better hydrolyzing activity to meropenem than to imipenem compared to the other subtypes of IMP enzymes ( Yano et al, 2001 ). IMP is the second most common carbapenemase produced by P. aeruginosa regardless of whether the strain was isolated in Europe ( Hrabak et al, 2009 , 2011 ; Samuelsen et al, 2010 ), in Asia ( Xiong et al, 2006 ; Kouda et al, 2007 ; Nho et al, 2008 ; Ryoo et al, 2009 ; Azim et al, 2010 ; Khosravi et al, 2010 ; Koh et al, 2010 ; Tada et al, 2019 ; Yaghi et al, 2019 ), in North ( Gibb et al, 2002 ; Hanson et al, 2006 ), and South America ( Garza-Ramos et al, 2008 ; Kazmierczak et al, 2016b ), in Africa ( Kateete et al, 2016 ; Adam and Elhag, 2018 ), and in Oceania ( McCarthy et al, 2017 ; Figure 4 ). P. aeruginosa ST357 mostly produces IMP.…”

Section: Mechanisms Of Resistance To Carbapenems In P Aerumentioning

confidence: 99%

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

2021

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Carbapenem-resistant Pseudomonas aeruginosa is one of the major concerns in clinical settings impelling a great challenge to antimicrobial therapy for patients with infections caused by the pathogen. While membrane permeability, together with derepression of the intrinsic beta-lactamase gene, is the global prevailing mechanism of carbapenem resistance in P. aeruginosa, the acquired genes for carbapenemases need special attention because horizontal gene transfer through mobile genetic elements, such as integrons, transposons, plasmids, and integrative and conjugative elements, could accelerate the dissemination of the carbapenem-resistant P. aeruginosa. This review aimed to illustrate epidemiologically the carbapenem resistance in P. aeruginosa, including the resistance rates worldwide and the carbapenemase-encoding genes along with the mobile genetic elements responsible for the horizontal dissemination of the drug resistance determinants. Moreover, the modular mobile elements including the carbapenemase-encoding gene, also known as the P. aeruginosa resistance islands, are scrutinized mostly for their structures.

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“…Unlike most of the IMP types, which mostly have a defined geographical distribution, IMP-7 shows a global dissemination. So far, IMP-7 has been identified in patients in Canada [28], the Czech Republic [40], Japan [38], Malaysia [41], Slovakia [42], Denmark [43], Saudi Arabia [44] and Australia [45]. Moreover, regional spread of P. aeruginosa ST357 producing IMP-7 has been reported in central Europe [46,47].…”

Section: Discussionmentioning

confidence: 99%

Carbapenemase -producing Pseudomonas aeruginosa isolates from Turkey: first report of P. aeruginosa high-risk clones with VIM-5– and IMP-7–type carbapenemases in a tertiary hospital

Çekin

Dabos

Malkoçoğlu

et al. 2021

Diagnostic Microbiology and Infectious Disease

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We investigated the presence of carbapenemases in carbapenem-resistant Pseudomonas aeruginosa isolates, which were collected over a 14-month period in a Turkish hospital, with in-depth molecular characterization of carbapenemase-producing isolates. Among 45 study isolates; two isolates were identified as carbapenemase producers by both Carba NP and Carbapenem Inactivation Method (CIM) tests, and only one of them gave a positive result in PCR tests for a carbapenemase gene (blaVIM). Whole genome sequencing (WGS) of the two isolates revealed the presence of blaVIM-5 gene in an ST308 isolate while the other one expressed IMP-7 in an ST357 isolate, both STs are considered high-risk clones. The two carbapenemaseproducing isolates were multidrug resistant, as they harbored other resistance determinants, including a variant of the recently described plasmid-encoded fluoroquinolone resistance determinant crpP gene, crpP-2. We report for the first time P. aeruginosa high-risk clones carrying VIM-5-and IMP-7-type carbapenemases with multiple resistance determinants in Turkey.

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Draft Genome Sequence of an IMP-7-Producing Pseudomonas aeruginosa Bloodstream Infection Isolate from Australia

Cited by 6 publications

References 13 publications

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

Carbapenemase -producing Pseudomonas aeruginosa isolates from Turkey: first report of P. aeruginosa high-risk clones with VIM-5– and IMP-7–type carbapenemases in a tertiary hospital

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