Dracunculiasis (Guinea Worm Disease) Eradication

Ruiz‐Tiben, Ernesto; Hopkins, Donald R.

doi:10.1016/s0065-308x(05)61007-x

Cited by 101 publications

(97 citation statements)

References 15 publications

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“…These are niridazole (25 mg/kg/day daily for 10 days), thiabendazole (50 mg/kg for 3 days), metronidazole (400mg for an adult for 10-20 days). 10 Prevention strategies include: Guinea worm case detection with the continuous surveillance, Preventing transmission from each worm by treatment, cleaning and bandaging regularly the affected skin-area until the worm is completely expelled from the body, making drinking water safe: provision and maintenance of safe drinking water supply on priority in GW endemic villages, 11 By use of temephos, Filtering water of open water bodies before drinking in endemic areas through fine mesh (size 100 micrometers), or double layered cloth strainers to remove Cyclops, increasing awareness among endemic communities by health promotion and behaviour change.…”

Section: Managementmentioning

confidence: 99%

Guinea Worm Infestation Presenting as a Soft Tissue Swelling

Murali¹

2018

jebmh

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Section: Managementmentioning

confidence: 99%

Guinea Worm Infestation Presenting as a Soft Tissue Swelling

Murali¹

2018

jebmh

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“…Immersing or pouring water over the blister provides pain reliever. But this the moment that adult female is exposed to the external environment [15] During emergence of the limbs in open water sources it recognizes the temperature difference and releases the milky white liquid in the water which contains millions of immature larvae, when larvae released in water are ingested by copepods where they mount twice and become infective larvae within two weeks [16].…”

Section: Sonu Mishra and Virendra S Gomasementioning

confidence: 99%

Identification of Antigenic Determinants, Solvent Accessibility and MHC Binders of Antigen NADH Dehydrogenase Subunit 5 from a Little Dragon from Medina (Dracunculusmedinensis)

Mishra¹,

Gomase²

2016

Drug Des

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Dracunculiasis caused by the pathogen Dracunculus medinensis (a little dragon from Medina). The Cyclops is the intermediate host that ingests the larvae of parasite (D. medinensis), that later on ingested by the human from the contaminated stagnant unfiltered water from the water source. After an incubation period of a year these mature female worm comes towards the skin and start formation of a small round bulge on the skin by secreting an irritating chemical which causes severe pain. In this study we will summarize the potency of NADH dehydrogenase subunit 5 (mitochondrion) from Dracunculus medinensis with 527 amino acids. Antigenic peptide of NADHdehydrogenasesubunit5 protein is most suitable for subunit vaccine development because with single epitope, the immune response can be generated in large population. In this research, we used PSSM and SVM algorithms for the prediction of MHC class I and II binding peptide, antigenicity, Solvent accessibility, polar and nonpolar residue to analyse the regions that are likely exposed on the surface of proteins which are potentially antigenic that allows potential drug targets to identify active sites against infection as well as to design effective drug to treat it.

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“…Immersing or pouring water over the blister provides pain relief. But this the moment that adult female is exposed to the external environment [4]. During emergence of the limbs in open water sources it recognizes the temperature difference and releases the milky white liquid in the water which contains millions of immature larvae, when larvae released in water are ingested by copepods where they mount twice and become infective larvae within two weeks [5].…”

Section: Introductionmentioning

confidence: 99%

Study Hydrophobicity and Antigenicity of Cytochrome C Oxidase Subunit II from D. medinensis: New Prototype of Synthetic Vaccine Development

Mishra¹,

Gomase²

2016

Immunochem Immunopathol

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Cytochrome c oxidase subunit II, also known as cytochrome c oxidase polypeptide II which is an oligomeric enzyme. In this study Cytochrome c oxidase subunit 2 (mitochondrion) protein has been used to investigate its role in antigenicity. Cytochrome c oxidase subunit 2 protein sequences (230 aa protein) is analyzed through different types B-cell epitope prediction methods. We found that the region of maximal hydrophilicity is likely to be an antigenic site, having hydrophobic characteristics, because the terminal regions of antigen protein is solvent accessible and unstructured, antibodies against those regions are also likely to recognize the native protein. It was seen that an antigen protein is hydrophobic in nature and contains segments of low complexity and high-predicted flexibility. The predicted antigenic protein segments of Cytochrome c oxidase subunit 2 can take active part in the host immune reactions. In future study the predicted antigenic protein Cytochrome c oxidase subunit 2 fragments can be used in the investigation of MHC molecules binding and it can be the first bottlenecks in vaccine design.

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Dracunculiasis (Guinea Worm Disease) Eradication

Cited by 101 publications

References 15 publications

Guinea Worm Infestation Presenting as a Soft Tissue Swelling

Guinea Worm Infestation Presenting as a Soft Tissue Swelling

Identification of Antigenic Determinants, Solvent Accessibility and MHC Binders of Antigen NADH Dehydrogenase Subunit 5 from a Little Dragon from Medina (Dracunculusmedinensis)

Study Hydrophobicity and Antigenicity of Cytochrome C Oxidase Subunit II from D. medinensis: New Prototype of Synthetic Vaccine Development

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