DR, DQ and antigens are associated with localized cutaneous leishmaniasis in mexicans

Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

“…The participation of these two groups of loci occurs in an independent fashion, since there is a hotspot of recombination between DP and DQ, 8 out of 56 patients that were DQA*03011 also had DPA*0401 and none of the controls, furthermore no linkage disequilibrium between these two alleles was found. Our previous serological analysis of the disease in Mexican Mestizo patients demonstrated that DQ3 is a susceptibility marker, although no association was detected in the DR region [20], probably due to the low resolution of the serological typing for DR4 which does not allow revealing any subtype of this antigen [28]. In the present study a strong association of LCL was found with the allele DRB1*0407, and DQA1*03011 was also statistically increased.…”

“…However, it is interesting to emphasize that DQ3 has been demonstrated to be a susceptibility marker in other populations, like Caucasoid and Mulattos from Brazil with MCL, as well as in Venezuelan Mestizo families with LCL [16,17,19]. In a previous study, DP locus was also serologically typed using monoclonal antibodies and DPw4 was found significantly decreased in the patients [20]. DNA typing performed in the present analysis confirmed this finding, since the DPB1*0401 contributed in 23% of the protection to develop LCL.…”

“…In Venezuelan families the HLA-Bw22 DRw11-DQw7 haplotype was found significantly more frequent in affected compared to healthy siblings [19]. In a previous study done by some of us with the same Mexican Mestizo patients using class I and class II serological typing, DQ3 was found significantly increased and DPw4 was shown to be significantly decreased in the LCL patients [20]. Thus, a susceptibility gene associated with DQ region and a possible putative gene in or close to DPB1 locus was suggested.…”

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

“…66 in Mexican Mestizos with LCL, 67 in Brazilian Caucasians and Mulattos with MCL. 68 HLA-DR2 antigen is associated with protection in Mexicans 63 and in Brazilians.…”

“…63 A previous study in this same population showed a significant increase of HLA-DQ3 antigen and a decrease of -DPw4 antigen in patients affected with LCL. 67 In Brazilians, Petzl-Erler et al investigated the association of MCL with Classes I and II HLA molecules in Caucasians and mulattos; no significant difference was found for Class I HLA antigens between patients and controls. 68 However, for Class II HLA antigens an important association was found.…”