Doxorubicin toxicity. Onycholysis, plantar callus formation, and epidermolysis

Manalo, Felipe B.

doi:10.1001/jama.233.1.56

Cited by 12 publications

(4 citation statements)

References 3 publications

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“…Approximately 135 cases of chemotherapy‐induced onycholysis have been reported in the literature1‐18 in addition to the 5 we report in the current study, for a total of 140 reported cases (Table 1). The first toe was the most common site,5, 7, 13 and sometimes the only digit involved, but all digits (fingers and toes) were involved in at least 10 patients2, 3, 5, 8, 11, 12, 16–18 and multiple digits were involved in at least 10 patients 2, 4, 6, 13–15.…”

Section: Literature Review and Discussionmentioning

confidence: 53%

“…Anthracyclines and taxanes are the drugs most frequently associated with onycholysis. Anthracyclines without a taxane were administered to 32 patients,3–7, 12, 13, 15, 16 in 9 of whom they were the only drugs used. Excluding those patients who also received a taxane, doxorubicin caused onycholysis in 11 patients,3, 4, 12 whereas mitoxantrone caused onycholysis in 21 patients 6, 7, 13, 16.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Onycholysis as a complication of systemic chemotherapy

Hussain

Anderson

Salvatti

et al. 2000

Cancer

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BACKGROUND Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RESULTS Onycholysis occurred in 5 of 21 patients who received > 6 courses of weekly paclitaxel, developing in the summer months in all 5 patients. It did not occur in patients who received fewer weekly paclitaxel courses or those who were treated every 3 weeks. Onycholysis did not occur in 187 patients who received doxorubicin. Review of the literature revealed that onycholysis is nearly exclusively associated with anthracycline and taxane therapy. CONCLUSIONS Prolonged weekly paclitaxel, other taxanes, and anthracyclines cause onycholysis in some patients, which may be precipitated by exposure to sunlight. Patients receiving these drugs should protect their nails from sunlight. Cancer 2000;88:2367–71. © 2000 American Cancer Society.

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Section: Literature Review and Discussionmentioning

confidence: 53%

Section: Literature Review and Discussionmentioning

confidence: 99%

Onycholysis as a complication of systemic chemotherapy

Hussain

Anderson

Salvatti

et al. 2000

Cancer

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“…2 We report three cases of onycholysis that occurred during cytotoxic treatment without any manifestation of skin toxicity.…”

Section: Onycholysis Associated With Cytotoxic Drugsmentioning

confidence: 97%

“…2 Features of both patients' illnesses which are characteristic of hydralazine induced lupus include: prominent polyarthralgia; weight loss; positive ANA test with negative DNA binding; normocomplementaemia; prompt recovery on discontinuing hydralazine and subsequent prolonged ANA positivity.' Although drug induced lupus is usually characterised by limited organ disease and a less severe clinical course than idiopathic systemic lupus erythematosus,l the occasional development of rapidly progressive glomerulonephritis4 5 and vasculitis5 has recently been emphasised.…”

Section: Commentmentioning

confidence: 99%