Chemotherapy-Induced Transverse White Lines in the Fingernails

James, William D.; Odom, Richard B.

doi:10.1001/archderm.1983.01650280062018

Cited by 28 publications

(4 citation statements)

References 16 publications

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“…Trachyonychia is characterized by roughness of the nail plate, loss of lustre, opacity and nail brittleness (Table 7). 45 Twenty‐nail dystrophy is a rare condition of acquired trachyonychia, originally described as an idiopathic condition presenting in childhood, followed by later resolution. All 20 nails are involved, developing roughness, fragility and excessive longitudinal ridging.…”

Section: Widespread Nail Matrix Insultmentioning

confidence: 99%

Diseases of the generative nail apparatus. Part I: Nail matrix

2002

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Disorders of the generative structures of the nail produce a characteristic set of outcomes. The matrix is the seat of nail development and diseases or insults of this germinative epithelium will tell a story in the signs that unfold in the ensuing nail growth. This story will be influenced by the intensity, duration and extent of this pathology. A method of categorizing changes associated with the generative matrix of the nail will be presented.

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Section: Widespread Nail Matrix Insultmentioning

confidence: 99%

Diseases of the generative nail apparatus. Part I: Nail matrix

2002

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“…The exact pathogenesis of Muehrcke's lines is unknown. It may be related to oedema in nail bed due to hypoalbuminaemia or alteration of nail plate attachment to the nail bed owing to the vascular alteration following chemotherapy 11,12 . As all the involved children in our study had normal levels of serum albumin, the frequent occurrence of Muehrcke's lines is more likely to be caused by the less strong adhesion of the nail plate to the nail bed in the affected children.…”

Section: Discussionmentioning

confidence: 64%

Nail changes associated with chemotherapy in children

Chen

et al. 2006

Acad Dermatol Venereol

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“…The pathogenesis is unknown, possibly relating to oedema of the nail bed papillary dermal collagen and altered nail plate attachment. Other associations include cytotoxic drugs, 112,113 zinc deficiency 107 and following heart transplantation surgery 114 …”

Section: Widespread Nail Bed Insultsmentioning

confidence: 99%

Diseases of the generative nail apparatus. Part II: Nail bed

2002

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Nail bed insults may affect the resultant nail product in a number of ways. If focal in nature, the severity and duration of the insult will determine the appearance of the nail product. Widespread insults may alter the size, shape or colour of the nail plate. Nail bed insults tend to present with more immediacy than nail matrical insults, as there is no need to wait until the nail grows out until the sign is obvious. We are less interested in the history of the event, than we are with the clinical sign being presented to us. Should treatment be required for focal nail bed insults, treatment is likely to be local and curative. Widespread nail bed insults may be associated with systemic diseases and if a result of local problems these may be difficult to treat.

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Chemotherapy-Induced Transverse White Lines in the Fingernails

Cited by 28 publications

References 16 publications

Diseases of the generative nail apparatus. Part I: Nail matrix

Diseases of the generative nail apparatus. Part I: Nail matrix

Nail changes associated with chemotherapy in children

Diseases of the generative nail apparatus. Part II: Nail bed

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