Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and
            <i>In Vitro</i>
            Evaluation

Betancourt, Tania; Brown, Brandon; Brannon-Peppas, Lisa

doi:10.2217/17435889.2.2.219

Cited by 228 publications

(149 citation statements)

References 45 publications

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“…40 It is usually employed to incorporate lipophilic drugs into the carriers based on the interfacial deposition of a polymer. 41,42 Nanoprecipitation is performed using systems containing three basic ingredients, ie, the polymer, the polymer solvent, and the nonsolvent of the polymer. The solvent should be organic, miscible in water, and easily removed by evaporation.…”

Section: Nanoprecipitationmentioning

confidence: 99%

“…The pH-dependent release behavior could be a result of accelerated degradation of the polymer and decreasing ionic interaction between the drug and the polymer at an acidic pH. 42 Another approach to improve the efficacy and selectivity of cancer treatment is the application of hyperthermia in combination with traditional cancer therapeutics, such as radiation therapy and chemotherapy. 105,106 Hyperthermia makes some cancer cells more sensitive to radiation and can also enhance the effect of certain anticancer drugs, 106 thus allowing the use of decreased chemotherapy doses.…”

Section: Doxorubicinmentioning

confidence: 99%

See 1 more Smart Citation

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

393

265

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The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.

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Section: Nanoprecipitationmentioning

confidence: 99%

Section: Doxorubicinmentioning

confidence: 99%

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

393

265

View full text Add to dashboard Cite

show abstract

“…PLGA is the most investigated degradable polymer for biomedical applications and is used in sutures, drug delivery devices, and tissue engineering scaffolds. In fact, PLGA 10 : 90 (Vicryl ® , Ethicon) and the copolymer LA/GA ratio 90 : 10 (Panacryl ® , Ethicon) are used as suture materials [114,115] and microspheres, microcapsules, nanospheres, or nanofibers of PLGA are available to deliver chemotherapeutics [116,117], proteins [118], vaccines [119], antibiotics [120], analgesics [121], antiinflammatory [122], and siRNA [123,124]. Moreover, PLGA demonstrates great cell adhesion and good proliferation properties making it an excellent candidate for application in tissue engineering, as shown by the available scaffolds for the engineering of bone [125,126], cartilage [127], tendon [128] [129], skin [130], liver [131], and nerve tissues [132].…”

Section: Polyestersmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…[76][77][78] In the typical single-step process, PLGA is dissolved in an organic solvent (eg, acetonitrile). Separately, a preheated aqueous solution containing 4%-6% ethanol is used to dissolve lecithin and functionalized lipids (eg, PEG-DSPE).…”

Section: Core-shell Type Hybrid Nanoparticlesmentioning

confidence: 99%

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Sah¹,

Thoma²,

Desu³

et al. 2013

IJN

196

127

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Abstract:The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shelltype lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.

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Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and In Vitro Evaluation

Abstract: Nanoparticles formulated by nanoprecipitation of acid-ended poly(lactic-co-glycolic acid) were found to be able to control the release of doxorubicin in a pH-dependent manner and to effectively deliver high payloads of the drug in an active form to MDA-MB-231 breast cancer cells.

Cited by 228 publications

References 45 publications

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Biodegradable polymers for dental tissue engineering and regeneration

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

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