Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand, Rassoul; Sepehri, Nima; Manoochehri, Saeed; Rouhani, Hasti; Atyabi, Fatemeh

doi:10.2147/ijn.s18905

Cited by 389 publications

(285 citation statements)

References 153 publications

Supporting

Mentioning

265

Contrasting

Unclassified

Order By: Relevance

“…Because free drug and nanoparticles were investigated using the same concentration of minocycline, the improvement in antibacterial effect activity be due to better penetration of the nanoparticles into bacterial cells and better delivery of minocycline to its site of action. 7 Nanoparticles are capable of being endocytosed by phagocytic cells and releasing drug into those cells. 52,53 The minocycline-loaded nanoparticles could be suitable for delivery of minocycline to phagocytic cells to achieve better treatment of infection compared with treatment using free minocycline.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] PLGA is one of the most biocompatible and biodegradable polymers, and it has been widely studied for preparing drug-loaded nanoparticles. 6,7 Several methods, such as phase separation or coacervation, emulsification diffusion, spray-drying, and emulsion-solvent evaporation techniques have been used to prepare PLGA nanoparticles. [8][9][10][11] Using emulsion solvent evaporation methods, various drug molecules have been encapsulated into PLGA nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

Self Cite

View full text Add to dashboard Cite

Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity. Results: The nanoparticles prepared in this study were spherical, with an average particle size of 85-424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%) . oil/oil (5.5%) . water/oil/water (4.7%) . modified oil/water (4.1%) . nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug. Conclusion: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

“…[49] In fact, this outcome was derived from ester hydrolysis caused by acid-base catalysis. [50] 3. Poly(Lactic-co-Glycolic) Acid Copolymers…”

Section: Physical-chemical Propertiesmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

201

133

View full text Add to dashboard Cite

Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

show abstract

“…2 Poly lactide-co-glycolide (PLGA), from the polyester family of biodegradable polymers used frequently as controlled drug delivery systems, has been used by many researchers for passive and active targeting of anticancer agents. 6 This polymer has been widely used in biomedical manufacturing because of its biodegradability and biocompatibility. 7 Due to the hydrophobic nature of PLGA molecules, hydrophobic drugs, including most anticancer agents, can be easily loaded into PLGA nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Docetaxel immunonanocarriers as targeted delivery systems for HER2-positive tumor cells: preparation, characterization, and cytotoxicity studies

Koopaei

Dinarvand

Amini³

et al. 2011

IJN

Self Cite

View full text Add to dashboard Cite

Background The objective of this study was to develop pegylated poly lactide-co-glycolide acid (PLGA) immunonanocarriers for targeting delivery of docetaxel to human breast cancer cells. Methods The polyethylene glycol (PEG) groups on the surface of the PLGA nanoparticles were functionalized using maleimide groups. Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) antigens of cancer cells, used as the targeting moiety, was attached to the maleimide groups on the surface of pegylated PLGA nanoparticles. Nanoparticles prepared by a nanoprecipitation method were characterized for their size, size distribution, surface charge, surface morphology, drug-loading, and in vitro drug release profile. Results The average size of the trastuzumab-decorated nanoparticles was 254 ± 16.4 nm and their zeta potential was −11.5 ± 1.4 mV. The average size of the nontargeted PLGA nanoparticles was 183 ± 22 nm and their zeta potential was −2.6 ± 0.34 mV. The cellular uptake of nanoparticles was studied using both HER2-positive (SKBR3 and BT-474) and HER2-negative (Calu-6) cell lines. Conclusion The cytotoxicity of the immunonanocarriers against HER2-positive cell lines was significantly higher than that of nontargeted PLGA nanoparticles and free docetaxel.

show abstract

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Cited by 389 publications

References 153 publications

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Docetaxel immunonanocarriers as targeted delivery systems for HER2-positive tumor cells: preparation, characterization, and cytotoxicity studies

Contact Info

Product

Resources

About