Down's syndrome in the Lothian region of Scotland — 1978 to 1989

Ramsay, Colin N.; Ellis, Patricia; Zealley, Helen

doi:10.1016/0753-3322(91)90028-r

Cited by 31 publications

(14 citation statements)

References 8 publications

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“…For example, nearly all published data concerning Down's syndrome show long-term increases after Chernobyl (Zatsepin et al 2004;Sperling et al 1994;Metneki and Czeizel 2005;Bound et al 1995;Ramsay et al 1991). Significant ecological relative risks for stillbirths and birth defects are in the range of 1.005 to 1.020/kBq m −2 137 Cs.…”

Section: Sex Odds and Other Genetic Traits And Ionizing Radiationmentioning

confidence: 95%

The human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities

Scherb

Voigt

2011

Environ Sci Pollut Res

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Section: Sex Odds and Other Genetic Traits And Ionizing Radiationmentioning

confidence: 95%

The human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities

Scherb

Voigt

2011

Environ Sci Pollut Res

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“…This change in diagnostic method is the main explanation for the increasing trend of DS in other countries as well because the increase in early prenatal diagnoses of trisomy 21 in fetuses leading to terminations of pregnancy that would previously have aborted spontaneously [25,26,45,46]. Second, the possible effect of a change in maternal age was evaluated.…”

Section: Periodmentioning

confidence: 99%

Increasing total prevalence rate of cases with Down syndrome in Hungary

Métneki

Czeizel

2005

Eur J Epidemiol

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Recently the population-based large data set of the Hungarian Congenital Abnormality Registry showed an increase in the recorded total (birth + fetal) prevalence rate of informative offspring with Down syndrome. This finding was checked and confirmed in the completed data set due to the field study including all cytogenetic labs and prenatal diagnostic centres. The previous birth prevalence of 1.17 per 100 in the 1970s increased to 1.50 per 1000 between 1989 and 1999 with a maximum 1.77 in 1992. The completeness of the Registry was only 65.9% between 1970 and 1999, i.e. 30 years. One-third of cases had not been karyotyped, however, this figure is now about 10%. The major explanation of this increase is the significantly higher proportion of prenatally diagnosed fetuses with Down syndrome and an increasing number of women over 35. In addition better ascertainment may also contribute to this increase, but new etiological factors cannot also be excluded.

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“…Clusters of Down syndrome cases have been reported in several different European countries after the accident at Chernobyl: in West Berlin, 12 cases were observed 9 months after the accident, while only 2-3 were expected (32). An abnormally high prevalence was also noted in the region of Lothian, Scotland (33). EUROCAT (European Registration of Congenital Anomalies), a network of regional registers monitoring congenital malformations, was called upon to assess the significance of these clusters.…”

Section: Case Clusters In Europe and Asia Minormentioning

confidence: 99%