Double-blind, randomized controlled clinical trial on analgesic efficacy of local anesthetics articaine and bupivacaine after impacted third molar extraction

Abstract

ACTRN12617001138370.

Pharmacological and Non-Pharmacological Methods of Postoperative Pain Control Following Oral and Maxillofacial Surgery: A Scoping Review

“…In a 2017 study by Olmedo-Gaya et al, patient's taking no rescue medication and given bupivacaine during the removal of impacted third molars reported significantly lower VAS scores at all times during the first 48 hours postoperative except for hour 8 compared to when articaine was used. 36 Patient's taking rescue medication and given bupivacaine reported significantly lower VAS scores within the first 8 hours postoperatively compared to those given articaine, but no difference in VAS scores between the 2 groups were reported after 8 hours. 36 Furthermore, liposomal bupivacaine (EXPAREL), has also been explored as a method of postoperative pain control.…”

“…36 Patient's taking rescue medication and given bupivacaine reported significantly lower VAS scores within the first 8 hours postoperatively compared to those given articaine, but no difference in VAS scores between the 2 groups were reported after 8 hours. 36 Furthermore, liposomal bupivacaine (EXPAREL), has also been explored as a method of postoperative pain control. Liposomal bupivacaine contains 3% free bupivacaine, which provides peak anesthesia about 1 hour following administration, and bupivacaine contained within liposomes, which provides peak anesthesia 12 to 36 hours following administration and is detectable for up to 72 to 96 hours.…”

Comparison of the effects of articaine and bupivacaine in impacted mandibular third molar tooth surgery: a randomized, controlled trial

“…The present study demonstrated that the total amount of rescue medication was lower and the time to ingestion of the first rescue analgesic was higher in the bupivacaine group, but no statistically significant difference was observed between the two solutions. Olmeda-Gaya et al [ 2 ] used paracetamol as a rescue analgesic medication in their study, and the rescue analgesic consumption in the articaine group was greater than that in the bupivacaine group. In addition, the time to ingestion of the first rescue medication was shorter in the articaine group, but the difference was not significant, similar to the findings in our study.…”

“…Postoperative pain is induced by intraoperative trauma and the release of chemical mediators, such as histamine, serotonin, quinine, and arachidonic acid [ 1 ]. In postoperative pain control, the combination of short-acting local anesthetics and nonsteroidal anti-inflammatory drugs (NSAIDs) is used frequently; however, the application of long-acting local anesthetics is also effective in managing postoperative pain [ 2 3 ].…”

“…The administration of long-acting local anesthetics decreases pain level and duration, especially in the first 6–8 hours after oral administration [ 2 4 5 6 ]. Furthermore, some authors have claimed that long-acting local anesthetics decrease the total amount of analgesic use due to their residual analgesic effect [ 4 6 ].…”