Double-blind comparison of addition of acanthopanax senticosus versus fluoxetine to lithium for treatment of adolescent patients with bipolar depression

Abstract

negative life events(P¼.033);more maternal interfere and protection(P¼.024). Conclusions: Our retrospective findings indicate that a history of automutilation behavior and suicidal ideation is associated with a more negative life events and more negative parental rearing style. Greater attention to realizing those at high risks for self-injury behavior and suicidal thinking could have an impact on bipolar disorder among adolescents.

The effectiveness and safety of herbal medicine on suicidal behavior: A PRISMA-compliant systematic review and meta-analysis

“…As a result, 2 case reports, [25,26] 3 studies with no suicide-related outcomes, [27][28][29] 1 study using herbal injections, [30] and 1 study using the same HM in the treatment and control groups [31] were excluded. Finally, 13 articles [32][33][34][35][36][37][38][39][40][41][42][43][44] were included in this review (Fig. 1).…”

“…All studies included in this review [32][33][34][35][36][37][38][39][40][41][42][43][44] were published between 2005 and 2019 and were RCTs; no CCTs or before-after study designs were included. Of the included studies, 7 [33][34][35]38,39,41,43] were published in journals; 5 [32,37,40,42,44] were theses; and one [36] was a conference proceeding abstract. All included studies were conducted in China, with most [32][33][34][35][36][37][38][39][40][41][42][43][44] published there.…”

“…Of the included studies, 7 [33][34][35]38,39,41,43] were published in journals; 5 [32,37,40,42,44] were theses; and one [36] was a conference proceeding abstract. All included studies were conducted in China, with most [32][33][34][35][36][37][38][39][40][41][42][43][44] published there. With the exception of 2 3-arm RCTs, [34,40] the remaining studies [32,33,[35][36][37][38][39][41][42][43][44] were 2-arm RCTs.…”

“…All included studies were conducted in China, with most [32][33][34][35][36][37][38][39][40][41][42][43][44] published there. With the exception of 2 3-arm RCTs, [34,40] the remaining studies [32,33,[35][36][37][38][39][41][42][43][44] were 2-arm RCTs. The total number of participants across all studies was 1236 (range, 43-209), with a mean of 95.08 participants.…”

“…Two studies [35,38] recruited participants at risk of suicide, with Liu et al [35] recruiting patients with depression following suicide attempts, and Li [38] recruiting patients with depression and suicidal ideation. The remaining studies [32][33][34]36,37,[39][40][41][42][43][44] recruited patients with depression and reported suicidal behavior as an outcome but did not include suicidal behavior in their inclusion criteria. In total, 28 treatment or control groups were included, with 9 being the most common HM group (28.57%), followed by the fluoxetine group (n = 5; 17.86%), and the HM combined with fluoxetine group (n = 3; 10.71%).…”