negative life events(P¼.033);more maternal interfere and protection(P¼.024). Conclusions: Our retrospective findings indicate that a history of automutilation behavior and suicidal ideation is associated with a more negative life events and more negative parental rearing style. Greater attention to realizing those at high risks for self-injury behavior and suicidal thinking could have an impact on bipolar disorder among adolescents.
Studies have indicated that early-life or early-onset depression is associated with a 2- to 4-fold increased risk of developing Alzheimers disease (AD). In AD, aggregation of an abnormally phosphorylated form of the tau protein may be a key pathological event. Tau is known to play a major role in promoting microtubule assembly and stabilization, and in maintaining the normal morphology of neurons. Several studies have reported that stress may induce tau phosphorylation. The main aim of the present study was to investigate possible alterations in the tau protein in the hippocampus and frontal cortex of 32 male Sprague-Dawley rats exposed to chronic unpredictable mild stress (CUMS) and then re-exposed to CUMS to mimic depression and the recurrence of depression, respectively, in humans. We evaluated the effects of CUMS, fluoxetine, and CUMS re-exposure on tau and phospho-tau. Our results showed that a single exposure to CUMS caused a significant reduction in sucrose preference, indicating a state of anhedonia. The change in behavior was accompanied by specific alterations in phospho-tau protein levels, but fluoxetine treatment reversed the CUMS-induced impairments. Moreover, changes in sucrose preference and phospho-tau were more pronounced in rats re-exposed to CUMS than in those subjected to a single exposure. Our results suggest that changes in tau phosphorylation may contribute to the link between depression and AD.
Background and aims: The depression prevalence is 40-70% in teenagers.it is twice as many as boys. Insufficient parents' attention to psychosocial need satisfaction (PSNS) can be effective in teenagers depression. This research studied the depression and PSNS in girl students living in Kashan eIRAN 2006 Methods: It was a Descriptive-Cross sectional research that studied 509 high school students whom were selected randomly from the schools of Kashan 2006.The Beck questionnaire were used for depression determination ;scores less than 5,5-7,8-15and more than 16 were considered normal, mild, moderate and sever depression. The PSNS was studied by a researcher made questionnaire that its reliability and validity has been assessed scores which were considered for low psns was 1-31,moderate was 32-62 and high psns was 63-93. X2 and T test were used to analyze the data. Results: The research showed that 53/3% of girls was depressed. The high PSNS were 49/9%, 62/2%, 84/1% and 87/3% in sever,moderate,mild and no depression girls respectively which showed significant direct relationship between PSNS and depression. The girl who were fully satisfied of psychosocial needs showed just 2/9% severe depression while the depression was 50% among girls with low PSNS (p<0/05). Conclusions: The parents' attention to psychosocial needs of teenagers can decrease depression in teenagers.
scores predicted lower intensity ratings accounting for about 10% of the variance in both conditions. EPQ-Extraversion and EPQ-Neuroticism explained 15% of the variance in TTR but in opposite directions. Higher EPQ-Neuroticism scores predicted lower SCR amplitude accounting for 8% of the variance. Conclusions: Measures of emotional reactivity show distinct patterns depending on experimental condition and personality characteristics.
Object To know the treatment experiences of patients with depression in general hospital, and their suggestion on the present mental health services. To provides theoretical support for optimizing the mental health services model in general hospital. Methods Qualitative interviews were given to 10 patients diagnosed as depressive disorder from department of psychiatry, Renmin Hospital of Wuhan University. Questions were asked from following aspects: the process of seeking medical help before hospitalization in psychiatry department(when, where, who, referral), evaluation of drug treatment (efficacy, side effects, doctors) and psychotherapy, satisfaction and suggestions on medical services(including hospital environment, medical staff and etc.), social rehabilitation (stigma, social functional recovery, survival / quality of life etc.), socioeconomic factors (health insurance coverage, financial resources, social support resources). Answers referred to above factors were conducted to statistical analysis. Results showed departments of neurology, gastroenterology, endocrinology, Chinese traditional medicine, obstetrics and gynecology are the first medical choice of depressive patients; the average number of departments before they get psychiatric treatment is five, the average number of referral is 2. Medication side effects are the most concerned problems. Enough and reasonable information given from doctor about drug's name, efficacy, side effects, and length of treatment can improve patient's compliance, even can predict recurrence rate. Discrimination medical personnel can reduce compliance of patients: contempt, pessimism, avoidance, activity limitations, and impolite language and behavior. Psychotherapy can shorten the hospital stay. Health insurance coverage, job, social support can predict social functional recovery. Conclusions Doctors in general hospital should improve their ability in recognizing depression to ensure referral patients timely; Education of depression, medication-related knowledge should offered by psychiatrists to improve patients’ treatment compliance, and reduce relapse rate; psychological therapy should be incorporated into psychiatric conventional treatment; Medical personnel should be conscious of using positive affirmation, respectful words and actions; effective communication with families is necessary for promoting patients’ social rehabilitation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.