Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis

Cox, Christopher; Clarkson, Thomas W.; Marsh, David O.; Amin-Zaki, Laman; Tikriti, S; Myers, Gary

doi:10.1016/s0013-9351(89)80075-1

Cited by 191 publications

(99 citation statements)

References 19 publications

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“…Another methodology that has sometimes been used to identify no-effect levels is nonparametric regression (31,32). Nonparametric regression fits a series of curves in overlapping segments corresponding to small regions of the dose-response relationship, to which a scatterplot smoothing technique is then applied.…”

Section: Discussionmentioning

confidence: 99%

A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls.

Jacobson

Janisse

Banerjee

et al. 2002

Environ Health Perspect

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Benchmark dose (BMD) analysis is used to determine levels of exposure to environmental contaminants associated with increased public health risk. In this study we used a benchmark approach to evaluate the risks associated with prenatal exposure to polychlorinated biphenyls (PCBs). We evaluated for intellectual impairment a cohort of children whose prenatal PCB exposure had been assessed from biologic specimens. We calculated BMDs and lower-bound confidence limits (BMDLs) for four end points using four sets of risk criteria. BMDLs were estimated using three different statistical methodologies. The BMDs and BMDLs were remarkably consistent across the four end points for each set of risk criteria, but differed substantially for the different risk criteria. The proportion of the sample considered at risk ranged from 9.8% for the least protective criteria to 74.1% for the most protective. Two methodologies, likelihood ratio and bootstrapping, generated generally similar BMDLs. BMD analysis provides a straightforward, reliable method for evaluating levels of exposure associated with increased public health risk. In the analyses performed in this study, the number of individuals considered at risk depended more on the risk criterion selected than on the outcome assessed.

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Section: Discussionmentioning

confidence: 99%

A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls.

Jacobson

Janisse

Banerjee

et al. 2002

Environ Health Perspect

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“…Episodes of fetal CH 3 Hg poisoning confirm that the developing brain is especially susceptible to Hg toxicity (63)(64)(65)(66). Minamata Disease, or CH 3 Hg poisoning, was first recognized in 1956 around Minamata Bay (61) and occurred again in 1965 in the Agano River Basin in Niigata, Japan (67).…”

Section: Why Is the Issue Of Determining A Hg Threshold Troubled By Cmentioning

confidence: 99%

Mercury Information Clearinghouse

Wocken¹,

Holmes²,

Laudal³

et al. 2006

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“…A group of mother and infant pairs were examined for the delay in developmental milestones such as walking and talking and the mothers' exposure to mercury, with the hair mercury content of each mother analyzed to determine the peak mercury concentration during pregnancy. Statistical analysis established a doseresponse relationship between the peak mercury concentration during pregnancy and whether first walking or talking was observed or not at the age of 18 or 24 months [48][49][50] . Based on this dose-response relationship, WHO 51) claimed that "A prudent interpretation of the Iraqi data implies that a 5% risk may be associated with the peak mercury level of 10-20 µ/g in maternal hair.…”

Section: Effects Of In Utero Methylmercury Exposurementioning

confidence: 99%

Occupational and Environmental Toxicology of Mercury and Its Compounds.

Satoh

2000

INDUSTRIAL HEALTH

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Mercury exists in various chemical forms. The important forms from a toxicological viewpoint are the metallic form, also called the elemental form, the divalent inorganic forms and methylmercury compounds. Elemental (Hg 0 ) mercury has a high vapor pressure and the vapor causes a number of cases of poisoning via inhalation. Classical mercury poisoning is characterized by a triad of signs, namely tremors, erethism and gingivitis. Mercurial erethism, which is characterized by behavioral and personality changes such as extreme shyness, excitability, loss of memory, and insomnia are also observed. Recently, the effects of mercury exposure at levels around 0.05 mg/m 3 or lower have been of concern and may include minor renal tubular damage, increased complaints of tiredness, memory disturbance and other symptoms, subclinical finger tremor, abnormal EEG by computerized analysis and impaired performance in neurobehavioral or neuropsychological tests. Abnormal gait, dysarthria, ataxia, deafness and constriction of the visual field are typical of the symptoms of methylmercury poisoning observed in Minamata and Iraqi outbreaks, as well as in occupational methylmercury poisoning cases. Furthermore, an infant born to a mother with excessive methylmercury consumption showed various neurological disturbances and delayed development. Since several populations are believed to be still exposed to methylmercury through the consumption of fish and sea mammals, neurobehavioral deviations in children of these populations have recently been investigated.

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Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis

Cited by 191 publications

References 19 publications

A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls.

A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls.

Mercury Information Clearinghouse

Occupational and Environmental Toxicology of Mercury and Its Compounds.

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