Dose-related effects of chronic resveratrol administration on neurogenesis, angiogenesis, and corticosterone secretion are associated with improved spatial memory retention following global cerebral ischemia

Girbovan, Catrinel; Kent, Pamela; Merali, Zul; Plamondon, Hélène

doi:10.1179/1476830515y.0000000020

Cited by 25 publications

(35 citation statements)

References 78 publications

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“…The effects of RSV, surprisingly, range widely from inflammation to fibrogenesis, angiogenesis, and collagen synthesis (Chen & Tseng, ; Li et al ., ). However, contradictory results exist as to whether RSV exerts pro‐ or anti‐ effects on angiogenesis and cell viability (Chen & Tseng, ), which might be dose‐dependent (Girbovan et al ., ). Here, we demonstrated that effects of RSV on wound healing are indeed conditionally beneficial.…”

Section: Discussionmentioning

confidence: 97%

Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

et al. 2017

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SummaryCutaneous wounds are among the most common soft tissue injuries and are particularly hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; pharmacologically, profound rejuvenative effects of CR mimetics have been uncovered, especially metformin (MET), resveratrol (RSV), and rapamycin (RAPA). However, locally applied impacts and functional differences of these agents on wound healing remain to be established. Here, we discovered that chronic topical administration of MET and RSV, but not RAPA, accelerated wound healing with improved epidermis, hair follicles, and collagen deposition in young rodents, and MET exerted more profound effects. Furthermore, locally applied MET and RSV improved vascularization of the wound beds, which were attributed to stimulation of adenosine monophosphate‐activated protein kinase (AMPK) pathway, the key mediator of wound healing. Notably, in aged skin, AMPK pathway was inhibited, correlated with impaired vasculature and reduced healing ability. As therapeutic approaches, local treatments of MET and RSV prevented age‐related AMPK suppression and angiogenic inhibition in wound beds. Moreover, in aged rats, rejuvenative effects of topically applied MET and RSV on cell viability of wound beds were confirmed, of which MET showed more prominent anti‐aging effects. We further verified that only MET promoted wound healing and cutaneous integrity in aged skin. These findings clarified differential effects of CR‐based anti‐aging pharmacology in wound healing, identified critical angiogenic and rejuvenative mechanisms through AMPK pathway in both young and aged skin, and unraveled chronic local application of MET as the optimal and promising regenerative agent in treating cutaneous wound defects.

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Section: Discussionmentioning

confidence: 97%

Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

et al. 2017

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“…A pharmacotoxicity study, conducted in mice, reported that dietary intake of PTE (0e3000 mg/kg body weight/day) for 28 days produced no significant change in body weight, food intake, organ weight, or other clinical signs (Ruiz et al, 2009), whereas oral intake of PTE at 250 g/day caused reduction in blood pressure, body weight and an increase in LDL cholesterol among hypertensive patients (Riche et al, 2014). However, recent studies suggest that chronic administration of RES may produce the plasma levels needed for biological activity (Girbovan et al, 2015;Mohammadshahi et al, 2014). Similarly, in a study using male Wistar rats, a chronic i.p.…”

Section: Discussionmentioning

confidence: 95%

“…Similarly, PTE concentration in certain grapes and berries ranges from 99 to 520 ng/g dry sample (Rimando et al, 2004). Therefore, most studies have used RES or PTE at much higher doses than would normally be achievable in the diet through consumption of red wine, fruit, or seeds (Girbovan et al, 2015;Mohammadshahi et al, 2014;Sharma and Gupta, 2002). A pharmacotoxicity study, conducted in mice, reported that dietary intake of PTE (0e3000 mg/kg body weight/day) for 28 days produced no significant change in body weight, food intake, organ weight, or other clinical signs (Ruiz et al, 2009), whereas oral intake of PTE at 250 g/day caused reduction in blood pressure, body weight and an increase in LDL cholesterol among hypertensive patients (Riche et al, 2014).…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, in a study using male Wistar rats, a chronic i.p. dose of 20 mg/kg/day of RES for 21 days was required to induce neurogenesis, angiogenensis, and neuronal survival in the hippocampus following global cerebral ischemia and thereby improve cognitive function (Girbovan et al, 2015). Therefore, it is imperative to improve the bioavailability of RES and PTE, possibly through structural modification, coadministration or timing, in order to attain pharmacological benefits.…”

Section: Discussionmentioning

confidence: 99%

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Effects of pterostilbene and resveratrol on brain and behavior

Poulose

Thangthaeng

Miller

et al. 2015

Neurochemistry International

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“…The underlying protective mechanisms of resveratrol are associated with the upregulation of cAMP response element-binding protein-BDNF or the reduction of oxidative stress. A recent study revealed that chronic resveratrol administration exhibited beneficial effects on spatial memory retention following global cerebral ischemia (17). However, the protective effects of resveratrol on CRS-induced cognitive deficits and the underlying molecular mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol reversed chronic restraint stress-induced impaired cognitive function in rats

Zhang

Wang

Bai

et al. 2017

Molecular Medicine Reports

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Chronic stress occurs in everyday life, and often results in memory impairments and depressive symptoms. Resveratrol is a natural polyphenol that possesses numerous biological properties, including potent antidepressant‑like effects. The present study aimed to examine the effects of resveratrol treatment on chronic restraint stress (CRS)‑induced cognitive impairment and to explore the underlying molecular mechanisms. Male Wistar rats were exposed to CRS for 21 days in order to induce depressive‑like behavior. The results demonstrated that CRS (6 h/day, 21 days) was able to induce cognitive deficits in rats, as evidenced by Morris water maze and novel object recognition tests. In addition, CRS exposure significantly decreased the mRNA and protein expression levels of hippocampal brain‑derived neurotrophic factor (BDNF) in the rats. Conversely, chronic treatment with resveratrol (80 mg/kg, i.p.; 21 days) significantly prevented the behavioral and biochemical alterations induced by CRS. The effects of resveratrol were nearly identical to those observed with fluoxetine treatment. In conclusion, the present study demonstrated that resveratrol may be a potential therapeutic agent for the treatment of chronic stress‑induced cognitive impairments, and its underlying molecular mechanism may be associated with the increased levels of hippocampal BDNF.

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Dose-related effects of chronic resveratrol administration on neurogenesis, angiogenesis, and corticosterone secretion are associated with improved spatial memory retention following global cerebral ischemia

Abstract: Our findings uncover time- and dose-related effects of RSV and global ischemia on the regulation of hippocampal plasticity. Changes in neuro- and angiogenesis are consistent with RSV neuroprotective effects, but appear independent of RSV regulatory effects on corticosterone secretion.

Cited by 25 publications

References 78 publications

Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

Effects of pterostilbene and resveratrol on brain and behavior

Resveratrol reversed chronic restraint stress-induced impaired cognitive function in rats

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