Dose point kernels in liquid water: An intra-comparison between GEANT4-DNA and a variety of Monte Carlo codes

Champion, C.; Incerti, S.; Perrot, Y.; Delorme, Rachel; Bordage, Marie‐Claude; Bardiès, Manuel; Mascialino, B.; Tran, H.N.; Ivanchenko, V. N.; Bernal, Mario A.; Francis, Z.; Groetz, Jean-Emmanuel; Fromm, M.; Campos, Laélia

doi:10.1016/j.apradiso.2013.01.037

Cited by 47 publications

(19 citation statements)

References 19 publications

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“…Geant4-DNA has been widely used for microdosimetric applications (e.g. Champion et al, 2014;Francis et al, 2011). Besides being an open source, well-documented, and widely used Monte Carlo simulation toolkit, the choice of Geant4 was made because, through its Geant4-DNA extension, it enables a collision-by-collision simulation of electron tracks (including secondary electron cascade) down to the excitation threshold of liquid water (7.4 eV).…”

Section: Introductionmentioning

confidence: 99%

Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Šefl

Incerti

Papamichael

et al. 2015

Applied Radiation and Isotopes

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Section: Introductionmentioning

confidence: 99%

Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Šefl

Incerti

Papamichael

et al. 2015

Applied Radiation and Isotopes

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“…The Dose Point Kernels (DPK), which represent the radial energy deposition distribution from point isotropic sources of electrons, are of great interest in targeted cellular therapy with electron-emitting radiopharmaceuticals, because they are the basis to calculate the dose at cellular level, required to estimate the radiobiological effect of the treatment [107]. Another quantity of interest for targeted cellular therapy is the S-value, which represents the dose to the target per unit of cumulated activity in the source region [108].…”

Section: Targeted Cellular Therapymentioning

confidence: 99%

“…Simulations of DPKs with Geant4-DNA were first simulated in liquid water by [107] using mono-energetic point source incident electrons in the 10 keV -100 keV range. Geant4-DNA was compared to other well-known Monte Carlo codes such as CPA100, EGSnrc, FLUKA, MCNPX and PENELOPE.…”

Section: Dose Point Kernelsmentioning

confidence: 99%

“…Geant4-DNA was compared to other well-known Monte Carlo codes such as CPA100, EGSnrc, FLUKA, MCNPX and PENELOPE. The reader is invited to consult [107] for code version numbers, code-specific settings used in the simulations and full original references. Using a Kolmogorov-Smirnov statistical test, the authors showed that Geant4-DNA is in agreement with EGSnrc, PENELOPE, and FLUKA and thus provides reliable results in the whole range of incident energies (10 keV -100 keV), and that significant differences are observed with CPA100 (for 30 keV and 50 keV incident energies) and with MCNPX (at all incident energies).…”

Section: Dose Point Kernelsmentioning

confidence: 99%

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Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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“…Diferentes tipos de Kernels podem ser utilizados, sendo os mais usados o kernel pontual e o do tipo pencil beam (figura 2.20). Usualmente, essas funções são derivadas de simulações de Monte Carlo [67]. O outro componente essencial da convolução/superposiçãoé a fluência de energia dos fótons usados no feixe clínico.…”

Section: Métodos Baseados Em Convolução/superposiçãounclassified

Desenvolvimento e avaliação de um sistema de cálculo de dose independente para controle de qualidade de IMRT do tipo jaws-only

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Dose point kernels in liquid water: An intra-comparison between GEANT4-DNA and a variety of Monte Carlo codes

Cited by 47 publications

References 19 publications

Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Review of Geant4-DNA applications for micro and nanoscale simulations

Desenvolvimento e avaliação de um sistema de cálculo de dose independente para controle de qualidade de IMRT do tipo jaws-only

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