Calculation of cellular S-values using Geant4-DNA: The effect of cell geometry

Šefl, Martin; Incerti, S.; Papamichael, G.; Emfietzoglou, Dimitris

doi:10.1016/j.apradiso.2015.06.027

Cited by 46 publications

(41 citation statements)

References 46 publications

(63 reference statements)

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“…svalue.in [6,73,74] slowing Slowing-down electron spectra slowing.in [72] microyz Microdosimetric distributions (lineal energy y, specific energy z) and related quantities microyz.in [60] TestEm12 (+) Dose point kernel dna.mac [6,59,75] TestEm5 (+) Identification of atomic de-excitation products for Geant4-DNA processes dna.mac -upper limit of Geant4-DNA electron models (available in the "option 2" constructor) using Geant4 electromagnetic physics models above this limit. In the current implementation of this interface, Geant4 electromagnetic physics models are taken from the "G4EmStandardPhysics_option4" standard electromagnetic physics constructor of Geant4.…”

Section: A1 Purposementioning

confidence: 99%

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Geant4‐DNA example applications for track structure simulations in liquid water: A report from the Geant4‐DNA Project

et al. 2018

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This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…). These example applications are included in the Geant4 Monte Carlo toolkit and are available in open access. Each application is described and comparisons to recent international recommendations are shown (e.g., ICRU, MIRD), when available. The influence of physics models available in Geant4-DNA for the simulation of electron interactions in liquid water is discussed. Thanks to these applications, the authors show that the most recent sets of physics models available in Geant4-DNA (the so-called "option4" and "option 6" sets) enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquid water, than the default set of models ("option 2") initially provided in Geant4-DNA. They also serve as reference applications for Geant4-DNA users interested in TS simulations.

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Section: A1 Purposementioning

confidence: 99%

“…87 presented in Ref. [74]. The public version of this example included in Geant4 10.4 calculates S-values for a single target sphere, whereas the version of this example described in this work will be released in the near future.…”

Section: F1 Purposementioning

confidence: 99%

Geant4‐DNA example applications for track structure simulations in liquid water: A report from the Geant4‐DNA Project

et al. 2018

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“…Finally, Sefl et al [112] performed a very detailed study of the influence of cellular geometry on S-values. They selected mono-energetic electrons (1 keV to 100 keV) and three Augeremitter radionuclides ( 99m Tc, 111 In and 125 I), which spectra were obtained from taken from the AAPM Report no.…”

Section: S-valuesmentioning

confidence: 99%

“…Three geometrical models were employed in order to simulate the cell geometry: one spherical model, two ellipsoid models and an irregular shape model. All geometries are fully described in [112]; they have the same cellular and nuclear volumes as the ellipsoid cell models proposed by MIRD and these volumes are equal to the volumes of a spherical cell with radius 5 micrometres and a spherical nucleus of radius 4 micrometres. Random and uniform sampling was presented in detail and was applied to all geometrical configurations, which is especially challenging in the case of non-spherical geometries.…”

Section: S-valuesmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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“…Results with Geant4-DNA (Fig. 8) are taken from (53) for the N N and N CS cases, with a spherical cell geometry (cell radius 5 lm; nucleus radius 4 lm). COOLER and PARTRAC results were obtained from dedicated calculations with the same cell model.…”

Section: Comparison To S-value Calculation With Geant4-dnamentioning

confidence: 99%