Dose per unit area - a study of elicitation of nickel allergy

Abstract

For elicitation of nickel allergy, the size of the exposed area and therefore the total amount of applied nickel, influence the elicitation reaction at some concentrations, even though the same dose per unit area is applied.

Prevalence of Nickel Allergy and Longitudinal Evaluation of Periodontal Abnormalities in Orthodontic Allergic Patients

“…11 Although recent studies have addressed the influence of nickel in the development of immune reactions in orthodontic patients, evidence on manifestations and the consequences that this material can have on oral and general health have been somewhat inconsistent. [12][13][14] Part of this problem can be explained by different study designs, small sample sizes, and different assessment methods, thereby leading to conflicting results and compromising the clinical application of such information. Specifically, the periodontal aspects of this issue have been rather under-explored in the literature.…”

Patch Testing for Metal Allergy With Manufacturer-Supplied Materials Before Nuss Bar Insertion

“…22Y25 Based on Danish and European Union regulations and confirmed by a number of studies, release of 0.5 Kg Ni/cm 2 per week is the level sufficient to elicit an ACD in a nickel sensitive individual. 25,26 Therefore, the negative DMG test indicates that the disc likely releases less than 0.5 Kg Ni/cm 2 per week, which is insufficient to elicit an ACD reaction in a nickel sensitive individual. The nickel present in the metal disc may be more tightly bound preventing its release.…”

Nickel-Free Alternatives Raise Awareness

“…If the concentration is at least 1:10,000, there is formation of a pink precipitate. 6 The greater the concentration of nickel, the more intense the pink color. 7 In addition, DMG may be used to test the operator, who is in contact with the nickel wares.…”