Dose estimation after a mixed field exposure: Radium-223 and intensity modulated radiotherapy

Bastiani, Isabella; McMahon, S. J.; Turner, Philip G.; Redmond, Keara L.; McGarry, Conor K.; Cole, Aidan; Prise, Kevin M.; Ainsbury, Liz; Anderson, Rhona M.

doi:10.1016/j.nucmedbio.2021.12.002

Cited by 6 publications

(4 citation statements)

References 72 publications

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“…However, M-FISH has not been used intensively due to the complexity of the analysis. Recently, some studies started to use this technique [ 83 , 84 , 85 , 86 , 87 , 88 ]; however, the resolution of chromosomes to identify complex rearrangements can be vastly improved when TC staining with M-FISH [ 17 , 18 , 89 ].…”

Section: Application Of Cytogenetic Tools In a Wider Spectrum Of Fiel...mentioning

confidence: 99%

High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview

M’Kacher

Colicchio

Junker

et al. 2023

IJMS

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In the event of a radiological or nuclear accident, or when physical dosimetry is not available, the scoring of radiation-induced chromosomal aberrations in lymphocytes constitutes an essential tool for the estimation of the absorbed dose of the exposed individual and for effective triage. Cytogenetic biodosimetry employs different cytogenetic assays including the scoring of dicentrics, micronuclei, and translocations as well as analyses of induced premature chromosome condensation to define the frequency of chromosome aberrations. However, inherent challenges using these techniques include the considerable time span from sampling to result, the sensitivity and specificity of the various techniques, and the requirement of highly skilled personnel. Thus, techniques that obviate these challenges are needed. The introduction of telomere and centromere (TC) staining have successfully met these challenges and, in addition, greatly improved the efficiency of cytogenetic biodosimetry through the development of automated approaches, thus reducing the need for specialized personnel. Here, we review the role of the various cytogenetic dosimeters and their recent improvements in the management of populations exposed to genotoxic agents such as ionizing radiation. Finally, we discuss the emerging potentials to exploit these techniques in a wider spectrum of medical and biological applications, e.g., in cancer biology to identify prognostic biomarkers for the optimal triage and treatment of patients.

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Section: Application Of Cytogenetic Tools In a Wider Spectrum Of Fiel...mentioning

confidence: 99%

High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview

M’Kacher

Colicchio

Junker

et al. 2023

IJMS

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“…According to Isabella Bastiani from Centre for Health Effects of Radiological and Chemical Agents, Brunel University London, 223Ra was discovered because of its unique characteristic that it can gather and stick around the bone and involved in bone turnover like calcium does, it also has a unique pharmacokinetic properties [17]. 223Ra quickly cleared through the gastrointestinal tract and the remainder through the kidneys.…”

Section: Ramentioning

confidence: 99%

Advancements in Alpha-Targeted Radiopharmaceuticals: A Rising star in Cancer Therapy

Tian

2023

HSET

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Currently, radiopharmaceuticals have emerged as a novel approach for tumor treatment. Alpha nuclides offer several advantages over beta nuclides, such as higher energy and a smaller radiation range. In recent years, alpha-targeted therapy has gradually developed, resulting in the approval and release of an increasing number of radiopharmaceuticals in the market. The text initially highlights the advantages of alpha nuclides in comparison to beta nuclides and Auger electrons. It then provides an overview of the fundamental structure and carrier selection of drugs used in alpha-targeted therapy. Furthermore, it presents a list of radiopharmaceuticals that were approved by the FDA between 2000 and 2020. Next, the clinical therapeutic effects and research status of three alpha nuclides are discussed, including 225Ac, 223Ra, and 227Th. These nuclides have received significant attention and are relatively mature in terms of research. Many of them have already undergone clinical trials. Finally, the text addresses the current research challenges and prospects of alpha-targeted drugs.

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“…Such studies are relatively uncommon compared to single-field studies, due to their additional experimental complexity and the limited clinical applicability as most patient treatments are delivered with a single modality. However, recent interest in combining different radiation qualities (including X-rays and alpha particle emitting radionuclides 17 , 18 , X-ray and protons 19 , 20 , and multi-ion treatments 21 ) have provided an impetus to explore this in greater detail.…”

Section: Introductionmentioning

confidence: 99%

High-LET radiation induces large amounts of rapidly-repaired sublethal damage

Liberal

Thompson

Prise

et al. 2023

Sci Rep

Self Cite

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There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clarify these effects by quantifying and modelling responses to X-ray and alpha particle combinations. Cells were exposed to X-rays, alpha particles, or combinations, with different doses and temporal separations. DNA damage was assessed by 53BP1 immunofluorescence, and radiosensitivity assessed using the clonogenic assay. Mechanistic models were then applied to understand trends in repair and survival. 53BP1 foci yields were significantly reduced in alpha particle exposures compared to X-rays, but these foci were slow to repair. Although alpha particles alone showed no inter-track interactions, substantial interactions were seen between X-rays and alpha particles. Mechanistic modelling suggested that sublethal damage (SLD) repair was independent of radiation quality, but that alpha particles generated substantially more sublethal damage than a similar dose of X-rays, $$RB{E}_{SLD}>2.8$$ R B E SLD > 2.8 . This high RBE may lead to unexpected synergies for combinations of different radiation qualities which must be taken into account in treatment design, and the rapid repair of this damage may impact on mechanistic modelling of radiation responses to high LETs.

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Dose estimation after a mixed field exposure: Radium-223 and intensity modulated radiotherapy

Cited by 6 publications

References 72 publications

High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview

High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview

Advancements in Alpha-Targeted Radiopharmaceuticals: A Rising star in Cancer Therapy

High-LET radiation induces large amounts of rapidly-repaired sublethal damage

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